The identity crisis of Hif-1α in HSC biology

Stephen M. Sykes

doi:10.1182/blood-2016-04-710459

The identity crisis of Hif-1α in HSC biology

Stephen M. Sykes

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

In this issue of Blood, Vukovic et al provide compelling data that hematopoietic stem cells (HSCs) do not require the transcription factor hypoxia-inducible factor 1α (Hif-1α) to duplicate themselves (ie, self-renew), reconstitute long-term hematopoiesis, or sustain hematopoiesis following injury. These observations affect hematology because they challenge previous notions regarding the role of Hif-1α in HSC biology.

Original language	English
Pages (from-to)	2782-2784
Number of pages	3
Journal	Blood
Volume	127
Issue number	23
DOIs	https://doi.org/10.1182/blood-2016-04-710459
State	Published - Jun 9 2016

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title = "The identity crisis of Hif-1α in HSC biology",

abstract = "In this issue of Blood, Vukovic et al provide compelling data that hematopoietic stem cells (HSCs) do not require the transcription factor hypoxia-inducible factor 1α (Hif-1α) to duplicate themselves (ie, self-renew), reconstitute long-term hematopoiesis, or sustain hematopoiesis following injury. These observations affect hematology because they challenge previous notions regarding the role of Hif-1α in HSC biology.",

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AB - In this issue of Blood, Vukovic et al provide compelling data that hematopoietic stem cells (HSCs) do not require the transcription factor hypoxia-inducible factor 1α (Hif-1α) to duplicate themselves (ie, self-renew), reconstitute long-term hematopoiesis, or sustain hematopoiesis following injury. These observations affect hematology because they challenge previous notions regarding the role of Hif-1α in HSC biology.

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The identity crisis of Hif-1α in HSC biology

Abstract

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