The identity crisis of Hif-1α in HSC biology

Research output: Contribution to journalComment/debate

3 Scopus citations

Abstract

In this issue of Blood, Vukovic et al provide compelling data that hematopoietic stem cells (HSCs) do not require the transcription factor hypoxia-inducible factor 1α (Hif-1α) to duplicate themselves (ie, self-renew), reconstitute long-term hematopoiesis, or sustain hematopoiesis following injury. These observations affect hematology because they challenge previous notions regarding the role of Hif-1α in HSC biology.

Original languageEnglish
Pages (from-to)2782-2784
Number of pages3
JournalBlood
Volume127
Issue number23
DOIs
StatePublished - Jun 9 2016

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