TY - JOUR
T1 - The human X-linked steroid sulfatase gene and a Y-encoded pseudogene
T2 - Evidence for an inversion of the Y chromosome during primate evolution
AU - Yen, Pauline H.
AU - Marsh, Birgit
AU - Allen, Elizabeth
AU - Tsai, Siao Ping
AU - Ellison, Jay
AU - Connolly, Lynn
AU - Neiswanger, Katherine
AU - Shapiro, Larry J.
PY - 1988/12/23
Y1 - 1988/12/23
N2 - The mammalian X and Y chromosomes are thought to have evolved from a common, nearly homologous chromosome pair. Although there is little sequence similarity between the mouse or the human X and Y, there are several regions in which moderate to extensive sequence homologies have been found, including, but not limited to, the so-called pseudoautosomal segment, in which X-Y pairing and recombination take place. The steroid sulfatase gene is in the psuedoautosomal region of the mouse, but not in man. We have cloned and characterized the human STS X-encoded locus and a pseudogene that is present on the long arm of the Y chromosome. Our data in humans and other primates suggest that there has been a pericentric inversion of the Y chromosome during primate evolution that has disrupted the former pseudoautosomal arrangement of these genes. These results provide additional insight into the evolution of the sex chromosomes and into the nature of this interesting portion of the human genome.
AB - The mammalian X and Y chromosomes are thought to have evolved from a common, nearly homologous chromosome pair. Although there is little sequence similarity between the mouse or the human X and Y, there are several regions in which moderate to extensive sequence homologies have been found, including, but not limited to, the so-called pseudoautosomal segment, in which X-Y pairing and recombination take place. The steroid sulfatase gene is in the psuedoautosomal region of the mouse, but not in man. We have cloned and characterized the human STS X-encoded locus and a pseudogene that is present on the long arm of the Y chromosome. Our data in humans and other primates suggest that there has been a pericentric inversion of the Y chromosome during primate evolution that has disrupted the former pseudoautosomal arrangement of these genes. These results provide additional insight into the evolution of the sex chromosomes and into the nature of this interesting portion of the human genome.
UR - http://www.scopus.com/inward/record.url?scp=0024208474&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(88)90257-7
DO - 10.1016/0092-8674(88)90257-7
M3 - Article
C2 - 3203382
AN - SCOPUS:0024208474
VL - 55
SP - 1123
EP - 1135
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -