The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family

Harold F. Sims; Martha L. Jennens; Mark E. Lowe

doi:10.1016/0378-1119(93)90307-O

The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family

Harold F. Sims
, Martha L. Jennens
, Mark E. Lowe

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The isolation and characterization of the human gene (hPL) encoding pancreatic lipase is reported. The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Gene
Volume	131
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(93)90307-O
State	Published - Sep 15 1993

Keywords

Recombinant DNA
canine
flanking sequences
introns
nucleotide sequencing
phylogeny
pseudogene
triglycerides

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10.1016/0378-1119(93)90307-O

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title = "The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family",

abstract = "The isolation and characterization of the human gene (hPL) encoding pancreatic lipase is reported. The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene.",

keywords = "Recombinant DNA, canine, flanking sequences, introns, nucleotide sequencing, phylogeny, pseudogene, triglycerides",

author = "Sims, \{Harold F.\} and Jennens, \{Martha L.\} and Lowe, \{Mark E.\}",

note = "Funding Information: This work was supported by NIH Grant DK33487 and was done during the tenure of an Established Investigatorship (M.E.L.) from the American Heart Association. The authors wish to thank Drs. A.W. Strauss and D. Perlmutter for their comments on the manuscript.",

year = "1993",

month = sep,

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doi = "10.1016/0378-1119(93)90307-O",

language = "English",

volume = "131",

pages = "281--285",

journal = "Gene",

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TY - JOUR

T1 - The human pancreatic lipase-encoding gene

T2 - structure and conservation of an Alu sequence in the lipase gene family

AU - Sims, Harold F.

AU - Jennens, Martha L.

AU - Lowe, Mark E.

N1 - Funding Information: This work was supported by NIH Grant DK33487 and was done during the tenure of an Established Investigatorship (M.E.L.) from the American Heart Association. The authors wish to thank Drs. A.W. Strauss and D. Perlmutter for their comments on the manuscript.

PY - 1993/9/15

Y1 - 1993/9/15

N2 - The isolation and characterization of the human gene (hPL) encoding pancreatic lipase is reported. The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene.

AB - The isolation and characterization of the human gene (hPL) encoding pancreatic lipase is reported. The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene.

KW - Recombinant DNA

KW - canine

KW - flanking sequences

KW - introns

KW - nucleotide sequencing

KW - phylogeny

KW - pseudogene

KW - triglycerides

UR - https://www.scopus.com/pages/publications/0027491120

U2 - 10.1016/0378-1119(93)90307-O

DO - 10.1016/0378-1119(93)90307-O

M3 - Article

C2 - 8406023

AN - SCOPUS:0027491120

SN - 0378-1119

VL - 131

SP - 281

EP - 285

JO - Gene

JF - Gene

IS - 2

ER -

The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family

Abstract

Keywords

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