TY - JOUR
T1 - The human immunodeficiency virus and the cardiometabolic syndrome in the developing world
T2 - an African perspective.
AU - Mutimura, Eugene
AU - Crowther, Nigel J.
AU - Stewart, Aimee
AU - Cade, W. Todd
PY - 2008
Y1 - 2008
N2 - The advent of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic disorder. Clinical care, however, needs to address the metabolic, anthropometric, and cardiovascular changes associated with HIV infection and HAART. Studies in developing countries suggest an increasing incidence of HIV-associated cardiometabolic syndrome (CMS), especially in urban settings. Predictions indicate that the greatest increase in the prevalence of diabetes will occur in Africa over the next 2 decades due to lifestyle changes. This, coupled with increased access to HAART, may exponentially increase the prevalence of CMS in developing countries, where HIV infection is prevalent. Appropriate evaluation and intervention programs need to be implemented in the developing world, especially sub-Saharan Africa, to curtail HIV-related CMS. This should include routine cardiovascular risk assessments, management of HIV infection with more "metabolically friendly" HAART, and encouragement of lifestyle modifications, particularly smoking cessation, weight management, regular exercise, and adherence to a healthy diet.
AB - The advent of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic disorder. Clinical care, however, needs to address the metabolic, anthropometric, and cardiovascular changes associated with HIV infection and HAART. Studies in developing countries suggest an increasing incidence of HIV-associated cardiometabolic syndrome (CMS), especially in urban settings. Predictions indicate that the greatest increase in the prevalence of diabetes will occur in Africa over the next 2 decades due to lifestyle changes. This, coupled with increased access to HAART, may exponentially increase the prevalence of CMS in developing countries, where HIV infection is prevalent. Appropriate evaluation and intervention programs need to be implemented in the developing world, especially sub-Saharan Africa, to curtail HIV-related CMS. This should include routine cardiovascular risk assessments, management of HIV infection with more "metabolically friendly" HAART, and encouragement of lifestyle modifications, particularly smoking cessation, weight management, regular exercise, and adherence to a healthy diet.
UR - http://www.scopus.com/inward/record.url?scp=65849360229&partnerID=8YFLogxK
U2 - 10.1111/j.1559-4572.2008.07584.x
DO - 10.1111/j.1559-4572.2008.07584.x
M3 - Article
C2 - 18453811
AN - SCOPUS:65849360229
SN - 1559-4564
VL - 3
SP - 106
EP - 110
JO - Journal of the cardiometabolic syndrome
JF - Journal of the cardiometabolic syndrome
IS - 2
ER -