The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

A. J. Parsian; J. E. Sheren; T. Y. Tao; P. C. Goswami; R. Malyapa; R. Van Rheeden; M. S. Watson; C. R. Hunt

doi:10.1016/s0167-4781(00)00203-7

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

A. J. Parsian, J. E. Sheren, T. Y. Tao, P. C. Goswami, R. Malyapa, R. Van Rheeden, M. S. Watson, C. R. Hunt

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Abstract

The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

Original language	English
Pages (from-to)	201-205
Number of pages	5
Journal	BBA - Biochimica et Biophysica Acta
Volume	1494
Issue number	1-2
DOIs	https://doi.org/10.1016/s0167-4781(00)00203-7
State	Published - Nov 15 2000

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title = "The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.",

abstract = "The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.",

author = "Parsian, {A. J.} and Sheren, {J. E.} and Tao, {T. Y.} and Goswami, {P. C.} and R. Malyapa and {Van Rheeden}, R. and Watson, {M. S.} and Hunt, {C. R.}",

note = "Funding Information: This work was supported by NCI Grants CA60757 (C.R.H.) and CA69593 (P.C.G.).",

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T1 - The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

AU - Parsian, A. J.

AU - Sheren, J. E.

AU - Tao, T. Y.

AU - Goswami, P. C.

AU - Malyapa, R.

AU - Van Rheeden, R.

AU - Watson, M. S.

AU - Hunt, C. R.

N1 - Funding Information: This work was supported by NCI Grants CA60757 (C.R.H.) and CA69593 (P.C.G.).

PY - 2000/11/15

Y1 - 2000/11/15

N2 - The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

AB - The human heat-inducible Hsp70B and Hsp70B' genes were co-localized to 1q23.1 by in situ hybridization. However, though transcripts from Hsp70B could be detected in heat-shocked cells, DNA sequence analyses of both the gene and cDNA copies of the mRNA indicate the gene is non-functional. Moreover, mouse homologues of Hsp70B/B' were not detected by Southern blot analysis, suggesting Hsp70B/B' arose from either Hsp70-1or Hsp70-2 after the divergence of mice and humans.

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U2 - 10.1016/s0167-4781(00)00203-7

DO - 10.1016/s0167-4781(00)00203-7

M3 - Article

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AN - SCOPUS:0034668827

SN - 0006-3002

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JO - BBA - Biochimica et Biophysica Acta

JF - BBA - Biochimica et Biophysica Acta

IS - 1-2

ER -

The human Hsp70B gene at the HSPA7 locus of chromosome 1 is transcribed but non-functional.

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