The human HNRPD locus maps to 4q21 and encodes a highly conserved protein

Laurie A. Dempsey, Ming Jie Li, Angela Depace, Patricia Bray-Ward, Nancy Maizels

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The hnRNP D protein interacts with nucleic acids both in vivo and in vitro. Like many other proteins that interact with RNA, it contains RBD (or 'RRM') domains and arg-gly-gly (RGG) motifs. We have examined the organization and localization of the human and murine genes that encode the hnRNP D protein. Comparison of the predicted sequences of the hnRNP D proteins in human and mouse shows that they are 96.9% identical (98.9% similar). This very high level of conservation suggests a critical function for hnRNP D. Sequence analysis of the human HNRPD gene shows that the protein is encoded by eight exons and that two additional exons specify sequences in the 3' UTR. Use of two of the coding exons is determined by alternative splicing of the HNRPD mRNA. The human HNRPD gene maps to 4q21. The mouse Hnrpd gene maps to the F region of chromosome 3, which is syntenic with the human 4q21 region.

Original languageEnglish
Pages (from-to)378-384
Number of pages7
JournalGenomics
Volume49
Issue number3
DOIs
StatePublished - May 1 1998

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