The Human Diabetes Proteome Project (HDPP): The 2014 update

D. Schvartz; P. Bergsten; K. H. Baek; A. Barba De La Rosa; J. Cantley; L. Dayon; F. Finamore; P. Fontana; P. Gaudet; Y. A. Goo; R. Moulder; D. Goodlett; J. D. Johnson; A. Konvalinka; H. Mulderm; F. Priego-Capote; S. Sechi; M. Snyder; A. Tiss; A. Wiederkehr; I. Xenarios; M. Kussmann; J. C. Sanchez

doi:10.1016/j.trprot.2015.03.001

The Human Diabetes Proteome Project (HDPP): The 2014 update

D. Schvartz
, P. Bergsten
, K. H. Baek
, A. Barba De La Rosa
, J. Cantley
, L. Dayon
, F. Finamore
, P. Fontana
, P. Gaudet
, Y. A. Goo
, R. Moulder
, D. Goodlett
, J. D. Johnson
, A. Konvalinka
, H. Mulderm
, F. Priego-Capote
, S. Sechi
, M. Snyder
, A. Tiss
, A. Wiederkehr

I. Xenarios, M. Kussmann, J. C. Sanchez

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Translational Proteomics
Volume	8-9
DOIs	https://doi.org/10.1016/j.trprot.2015.03.001
State	Published - Dec 1 2015

Keywords

B/D-HPP
Blood
Diabetes
HDPP
HPP
Human proteome
Islet
Network biology

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10.1016/j.trprot.2015.03.001

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Schvartz, D., Bergsten, P., Baek, K. H., De La Rosa, A. B., Cantley, J., Dayon, L., Finamore, F., Fontana, P., Gaudet, P., Goo, Y. A., Moulder, R., Goodlett, D., Johnson, J. D., Konvalinka, A., Mulderm, H., Priego-Capote, F., Sechi, S., Snyder, M., Tiss, A., ... Sanchez, J. C. (2015). The Human Diabetes Proteome Project (HDPP): The 2014 update. Translational Proteomics, 8-9, 1-7. https://doi.org/10.1016/j.trprot.2015.03.001

@article{4fb11a712af948d883fcf5df706e5169,

title = "The Human Diabetes Proteome Project (HDPP): The 2014 update",

abstract = "Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3\% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.",

keywords = "B/D-HPP, Blood, Diabetes, HDPP, HPP, Human proteome, Islet, Network biology",

author = "D. Schvartz and P. Bergsten and Baek, \{K. H.\} and \{De La Rosa\}, \{A. Barba\} and J. Cantley and L. Dayon and F. Finamore and P. Fontana and P. Gaudet and Goo, \{Y. A.\} and R. Moulder and D. Goodlett and Johnson, \{J. D.\} and A. Konvalinka and H. Mulderm and F. Priego-Capote and S. Sechi and M. Snyder and A. Tiss and A. Wiederkehr and I. Xenarios and M. Kussmann and Sanchez, \{J. C.\}",

note = "Publisher Copyright: {\textcopyright} 2015.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.trprot.2015.03.001",

language = "English",

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Schvartz, D, Bergsten, P, Baek, KH, De La Rosa, AB, Cantley, J, Dayon, L, Finamore, F, Fontana, P, Gaudet, P, Goo, YA, Moulder, R, Goodlett, D, Johnson, JD, Konvalinka, A, Mulderm, H, Priego-Capote, F, Sechi, S, Snyder, M, Tiss, A, Wiederkehr, A, Xenarios, I, Kussmann, M & Sanchez, JC 2015, 'The Human Diabetes Proteome Project (HDPP): The 2014 update', Translational Proteomics, vol. 8-9, pp. 1-7. https://doi.org/10.1016/j.trprot.2015.03.001

TY - JOUR

T1 - The Human Diabetes Proteome Project (HDPP)

T2 - The 2014 update

AU - Schvartz, D.

AU - Bergsten, P.

AU - Baek, K. H.

AU - De La Rosa, A. Barba

AU - Cantley, J.

AU - Dayon, L.

AU - Finamore, F.

AU - Fontana, P.

AU - Gaudet, P.

AU - Goo, Y. A.

AU - Moulder, R.

AU - Goodlett, D.

AU - Johnson, J. D.

AU - Konvalinka, A.

AU - Mulderm, H.

AU - Priego-Capote, F.

AU - Sechi, S.

AU - Snyder, M.

AU - Tiss, A.

AU - Wiederkehr, A.

AU - Xenarios, I.

AU - Kussmann, M.

AU - Sanchez, J. C.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

AB - Diabetes is an increasing worldwide problem leading to major associated health issues and increased health care costs. In 2012, 9.3% of the American population was affected by diabetes, according to the American Diabetes Association, with 1.7 million of new cases since during the year (www.diabetes.org). Proteome initiatives can provide a deeper understanding of the biology of this disease and help develop more effective treatments. The collaborative effort of the Human Diabetes Proteome Project (HDPP) brings together a wide variety of complementary resources to increase the existing knowledge about both type 1 and type 2 diabetes and their related complications. The goals are to identify proteins and protein isoforms associated with the pathology and to characterize underlying disease-related pathways and mechanisms. Moreover, a considerable effort is being made on data integration and network biology. Sharing these data with the scientific community will be an important part of the consortium. Here we report on: the content of the HDPP session held at the 12th HUPO meeting in Yokohama; recent achievements of the consortium; discussions of several HDPP workshops; as well as future HDPP directions as discussed at the 13th HUPO congress in Madrid, with a special attention given to the lists of prioritized, diabetes-related proteins and the proteomic means to study them.

KW - B/D-HPP

KW - Blood

KW - Diabetes

KW - HDPP

KW - HPP

KW - Human proteome

KW - Islet

KW - Network biology

UR - https://www.scopus.com/pages/publications/84994462692

U2 - 10.1016/j.trprot.2015.03.001

DO - 10.1016/j.trprot.2015.03.001

M3 - Article

AN - SCOPUS:84994462692

SN - 2212-9626

VL - 8-9

SP - 1

EP - 7

JO - Translational Proteomics

JF - Translational Proteomics

ER -

The Human Diabetes Proteome Project (HDPP): The 2014 update

Abstract

Keywords

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