The HTLV receptor is a widely expressed protein

Samuel R. Trejo; Lee Ratner

doi:10.1006/viro.2000.0143

The HTLV receptor is a widely expressed protein

Samuel R. Trejo, Lee Ratner

Research output: Contribution to journal › Article › peer-review

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Abstract

The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of celt lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under the control of an SV40 enhancer and promoter, infection by pseudotyped virus was blocked with neutralizing antibodies to HTLV-1, and infection was dependent on the presence of the cleavage and fusogenic sequences in the envelope protein precursor. Trypsin treatment of susceptible target lymphocytes reduced entry. Entry was partially resistant to ammonium chloride. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	41-48
Number of pages	8
Journal	Virology
Volume	268
Issue number	1
DOIs	https://doi.org/10.1006/viro.2000.0143
State	Published - Mar 1 2000

Keywords

Envelope
Human T-cell leukemia virus
Pseudotype
Receptor

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10.1006/viro.2000.0143

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title = "The HTLV receptor is a widely expressed protein",

abstract = "The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of celt lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under the control of an SV40 enhancer and promoter, infection by pseudotyped virus was blocked with neutralizing antibodies to HTLV-1, and infection was dependent on the presence of the cleavage and fusogenic sequences in the envelope protein precursor. Trypsin treatment of susceptible target lymphocytes reduced entry. Entry was partially resistant to ammonium chloride. (C) 2000 Academic Press.",

keywords = "Envelope, Human T-cell leukemia virus, Pseudotype, Receptor",

author = "Trejo, {Samuel R.} and Lee Ratner",

note = "Funding Information: We thank Michael Robek and Nancy Vander Heyden for critical discussions. This work was supported by U.S. Public Health Service grant CA 63417.",

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N2 - The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of celt lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under the control of an SV40 enhancer and promoter, infection by pseudotyped virus was blocked with neutralizing antibodies to HTLV-1, and infection was dependent on the presence of the cleavage and fusogenic sequences in the envelope protein precursor. Trypsin treatment of susceptible target lymphocytes reduced entry. Entry was partially resistant to ammonium chloride. (C) 2000 Academic Press.

AB - The receptor for human T-cell leukemia virus type 1 (HTLV-1) was found to be expressed on a broad range of celt lines derived from multiple species. Receptor expression was assessed using human immunodeficiency virus type 1 particles, pseudotyped with the HTLV-1 envelope glycoprotein, and expressing luciferase under the control of an SV40 enhancer and promoter, infection by pseudotyped virus was blocked with neutralizing antibodies to HTLV-1, and infection was dependent on the presence of the cleavage and fusogenic sequences in the envelope protein precursor. Trypsin treatment of susceptible target lymphocytes reduced entry. Entry was partially resistant to ammonium chloride. (C) 2000 Academic Press.

KW - Envelope

KW - Human T-cell leukemia virus

KW - Pseudotype

KW - Receptor

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The HTLV receptor is a widely expressed protein

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Keywords

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