The host immunologic response to West Nile encephalitis virus

Michael S. Diamond, Erin Mehlhop, Theodore Oliphant, Melanie A. Samuel

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations

Abstract

West Nile encephalitis virus (WNV) is a small, enveloped, mosquito-transmitted, positive-polarity RNA virus of the Flaviviridae family. This virus is closely related to other arthropod-borne viruses that cause human disease including Dengue, Yellow fever, and Japanese encephalitis viruses. WNV cycles in nature between mosquitoes and birds, but also infects human, horses, and other vertebrates. In humans, WNV disseminates to the central nervous system (CNS) and causes severe disease primarily in the immunocompromised and elderly. Experimental studies have made significant progress in dissecting the viral and host factors that determine the pathogenesis and outcome of WNV infection. This review will focus on the interactions between WNV and the protective and pathogenic host immune responses.

Original languageEnglish
Pages (from-to)3024-3040
Number of pages17
JournalFrontiers in Bioscience
Volume14
Issue number8
DOIs
StatePublished - Jan 1 2009

Keywords

  • Antibody
  • Flavivirus
  • Immunology
  • Interferon
  • Pathogenesis
  • Review
  • T cells

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