The hitchhiker's guide to parasite dissemination

Lisa L. Drewry, L. David Sibley

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Toxoplasma gondii (T. gondii) is a parasitic protist that can infect nearly all nucleated cell types and tissues of warm-blooded vertebrate hosts. T. gondii utilises a unique form of gliding motility to cross cellular barriers, enter tissues, and penetrate host cells, thus enhancing spread within an infected host. However, T. gondii also disseminates by hijacking the migratory abilities of infected leukocytes. Traditionally, this process has been viewed as a route to cross biological barriers such as the blood–brain barrier. Here, we review recent findings that challenge this view by showing that infection of monocytes downregulates the program of transendothelial migration. Instead, infection by T. gondii enhances Rho-dependent interstitial migration of monocytes and macrophages, which enhances dissemination within tissues. Collectively, the available evidence indicates that T. gondii parasites use multiple means to disseminate within the host, including enhanced motility in tissues and translocation across biological barriers.

Original languageEnglish
Article numbere13070
JournalCellular microbiology
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • actin-based motility
  • central nervous system infection
  • microbial-cell interaction
  • pathogen dissemination
  • protein kinase
  • transendothelial migration

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