The History of Cellular Therapies

Zachary D. Crees, Armin Ghobadi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The approval of multiple CAR-T cell and T cell engaging products for lymphoma, leukemia and multiple myeloma in recent years, in addition to hundreds of active clinical trials in cancer using these platforms, marks the start of a new era in gene and cellular therapy for cancer. However, these remarkable achievements in medicine are built upon thousands of years of advancement in the understanding of cancer and immunity with rapid acceleration in the last few decades. In this chapter, we will broadly review historical aspects of gene and cellular therapy development, focusing on major milestones.

Original languageEnglish
Title of host publicationCancer Drug Discovery and Development
PublisherHumana Press Inc.
Pages3-11
Number of pages9
DOIs
StatePublished - 2022

Publication series

NameCancer Drug Discovery and Development
ISSN (Print)2196-9906
ISSN (Electronic)2196-9914

Keywords

  • Allogeneic hematopoietic cell transplantation
  • Chimeric antigen receptor T-cells (CAR-T)
  • Donor lymphocyte infusions (DLI)
  • Dual-targeting immune cell engaging therapies
  • Gene and cellular therapy history
  • Hippocrates
  • Ilya Metchnikoff
  • Mohammed ibn Zakariya al-Razi
  • Natural killer (NK) cells
  • Paul Ehrlich
  • Pillars of cancer care
  • Rudolph Virchow
  • T-cell receptor engineered T-cells (TCR-T)
  • Tumor infiltrating lymphocytes (TILs)
  • Viral cytotoxic T-lymphocytes (viral CTLs)
  • William Coley

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