The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers

Mark A. Sarzynski, Treva K. Rice, Jean Pierre Després, Louis Pérusse, Angelo Tremblay, Philip R. Stanforth, André Tchernof, Jacob L. Barber, Francesco Falciani, Clary Clish, Jeremy M. Robbins, Sujoy Ghosh, Robert E. Gerszten, Arthur S. Leon, James S. Skinner, D. C. Rao, Claude Bouchard

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and cardiovascular disease and diabetes risk factors. Here we summarize the findings and their potential implications for cardiometabolic health and cardiorespiratory fitness. It begins with overviews of background and planning, recruitment, testing and exercise program protocol, quality control measures, and other relevant organizational issues. A summary of findings is then provided on cardiorespiratory fitness, exercise hemodynamics, insulin and glucose metabolism, lipid and lipoprotein profiles, adiposity and abdominal visceral fat, blood levels of steroids and other hormones, markers of oxidative stress, skeletal muscle morphology and metabolic indicators, and resting metabolic rate. These summaries document the extent of the individual differences in response to a standardized and fully monitored endurance exercise program and document the importance of familial aggregation and heritability level for exercise response traits. Findings from genomic markers, muscle gene expression studies, and proteomic and metabolomics explorations are reviewed, along with lessons learned from a bioinformatics-driven analysis pipeline. The new opportunities being pursued in integrative-omics and physiology have extended considerably the expected life of HERITAGE and are being discussed in relation to the original conceptual model of the study.

Original languageEnglish
Pages (from-to)S1-S43
JournalMedicine and Science in Sports and Exercise
Volume54
Issue number5
DOIs
StatePublished - May 1 2022

Keywords

  • Cardiometabolic Risk Factors
  • Exercise And Bioinformatics
  • Exercise And Gene Expression
  • Exercise And Metabolomics
  • Exercise And Proteomics
  • Exercise Genomics
  • Exercise Training
  • Heritability

Fingerprint

Dive into the research topics of 'The HERITAGE Family Study: A Review of the Effects of Exercise Training on Cardiometabolic Health, with Insights into Molecular Transducers'. Together they form a unique fingerprint.

Cite this