TY - JOUR
T1 - The heritability of multi-modal connectivity in human brain activity
AU - Colclough, Giles L.
AU - Smith, Stephen M.
AU - Nichols, Thomas E.
AU - Winkler, Anderson M.
AU - Sotiropoulos, Stamatios N.
AU - Glasser, Matthew F.
AU - Van Essen, David C.
AU - Woolrich, Mark W.
N1 - Publisher Copyright:
© Colclough et al.
PY - 2017/7/26
Y1 - 2017/7/26
N2 - Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity among 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, have the dominant role in determining the coupling of neuronal activity.
AB - Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity among 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, have the dominant role in determining the coupling of neuronal activity.
UR - http://www.scopus.com/inward/record.url?scp=85030649292&partnerID=8YFLogxK
U2 - 10.7554/eLife.20178
DO - 10.7554/eLife.20178
M3 - Article
C2 - 28745584
AN - SCOPUS:85030649292
SN - 2050-084X
VL - 6
JO - eLife
JF - eLife
M1 - e20178
ER -