TY - JOUR
T1 - The hemodynamic response in children with Simplex Autism
AU - Feczko, Eric
AU - Miezin, Francis M.
AU - Constantino, John N.
AU - Schlaggar, Bradley L.
AU - Petersen, Steven E.
AU - Pruett, John R.
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012/10
Y1 - 2012/10
N2 - Background: Numerous functional magnetic resonance imaging (fMRI) studies of the brain-bases of autism have demonstrated altered cortical responses in subjects with autism, relative to typical subjects, during a variety of tasks. These differences may reflect altered neuronal responses or altered hemodynamic response. This study searches for evidence of hemodynamic response differences by using a simple visual stimulus and elementary motor actions, which should elicit similar neuronal responses in patients and controls. Methods: We acquired fMRI data from two groups of 16 children, a typical group and a group with Simplex Autism, during a simple visuomotor paradigm previously used to assess this question in other cross-group comparisons. A general linear model estimated the blood-oxygen-level-dependent (BOLD) signal time course, and repeated-measures analysis of variance tested for potential cross-group differences in the BOLD signal. Results: The hemodynamic response in Simplex Autism is similar to that found in typical children. Although the sample size was small for a secondary analysis, medication appeared to have no effect on the hemodynamic response within the Simplex Autism group. Conclusions: When fMRI studies show BOLD response differences between autistic and typical subjects, these results likely reflect between-group differences in neural activity and not an altered hemodynamic response.
AB - Background: Numerous functional magnetic resonance imaging (fMRI) studies of the brain-bases of autism have demonstrated altered cortical responses in subjects with autism, relative to typical subjects, during a variety of tasks. These differences may reflect altered neuronal responses or altered hemodynamic response. This study searches for evidence of hemodynamic response differences by using a simple visual stimulus and elementary motor actions, which should elicit similar neuronal responses in patients and controls. Methods: We acquired fMRI data from two groups of 16 children, a typical group and a group with Simplex Autism, during a simple visuomotor paradigm previously used to assess this question in other cross-group comparisons. A general linear model estimated the blood-oxygen-level-dependent (BOLD) signal time course, and repeated-measures analysis of variance tested for potential cross-group differences in the BOLD signal. Results: The hemodynamic response in Simplex Autism is similar to that found in typical children. Although the sample size was small for a secondary analysis, medication appeared to have no effect on the hemodynamic response within the Simplex Autism group. Conclusions: When fMRI studies show BOLD response differences between autistic and typical subjects, these results likely reflect between-group differences in neural activity and not an altered hemodynamic response.
KW - Autism spectrum disorders
KW - Event-related
KW - Functional magnetic resonance imaging
KW - Medication effects
KW - Neurovascular coupling
KW - Visuomotor
UR - http://www.scopus.com/inward/record.url?scp=84865085069&partnerID=8YFLogxK
U2 - 10.1016/j.dcn.2012.06.001
DO - 10.1016/j.dcn.2012.06.001
M3 - Article
C2 - 22795455
AN - SCOPUS:84865085069
VL - 2
SP - 396
EP - 408
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
SN - 1878-9293
IS - 4
ER -