The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Jia Shen, Xiangpeng Sheng, Ze Nan Chang, Qian Wu, Dong Xie, Fudi Wang, Ronggui Hu

Research output: Contribution to journalComment/debate

12 Scopus citations

Abstract

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.

Original languageEnglish
Article numbere965642
JournalMolecular and Cellular Oncology
Volume3
Issue number1
DOIs
StatePublished - Jan 2 2016

Keywords

  • heme
  • hemochromatosis
  • iron deprivation
  • nuclear export
  • p53
  • tumorigenesis

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