The Heart and Pediatric Rheumatology

Tiphanie Vogel, Maleewan Kitcharoensakkul, Lampros Fotis, Kevin Baszis

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Recent advances in Kawasaki disease have included attempts to define genes involved in its pathogenesis. There have been recent advances in the studies of rheumatic carditis, leading to a better understanding of the mechanism of the disease. Histologic evaluation of patients with neonatal lupus erythematosus has revealed fibrosis with collagen deposition and calcification of the atrioventricular node. Therapy for cardiac involvement in systemic juvenile idiopathic arthritis should involve treatment of the underlying disease and systemic inflammatory state, and typically includes nonsteroidal antiinflammatory drugs, corticosteroids, disease-modifying drugs, and biologic therapies targeting tumor necrosis factor-alpha, interleukin-1, and interleukin-6.

Original languageEnglish
Pages (from-to)61-85
Number of pages25
JournalRheumatic Disease Clinics of North America
Volume40
Issue number1
DOIs
StatePublished - Feb 1 2014

Keywords

  • Acute rheumatic fever
  • Juvenile dermatomyositis
  • Kawasaki disease
  • Marfan syndrome
  • Neonatal lupus
  • Poststreptococcal reactive arthritis
  • Systemic juvenile idiopathic arthritis

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