The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

Naomi G. Wilson, Ariel Hernandez-Leyva, Anne L. Rosen, Natalia Jaeger, Ryan T. McDonough, Jesus Santiago-Borges, Michael A. Lint, Thomas R. Rosen, Christopher P. Tomera, Leonard B. Bacharier, S. Joshua Swamidass, Andrew L. Kau

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S rRNA sequencing and find individuals with asthma harbored compositional differences from healthy controls in both adults and children. We develop a model to aid the design of mechanistic experiments in gnotobiotic mice and show enterotoxigenic Bacteroides fragilis (ETBF) is more prevalent in the gut microbiota of patients with asthma compared to healthy controls. In mice, ETBF, modulated by community context, can increase oxidative stress in the lungs during allergic airway inflammation (AAI). Our results provide evidence that ETBF affects the phenotype of airway inflammation in a subset of patients with asthma which suggests that therapies targeting the gut microbiota may be helpful tools for asthma control.

Original languageEnglish
Article number105991
JournaliScience
Volume26
Issue number2
DOIs
StatePublished - Feb 17 2023

Keywords

  • Immunity
  • Medical microbiology

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