TY - JOUR
T1 - The gut microbiome as a reservoir for antimicrobial resistance
AU - Anthony, Winston E.
AU - Burnham, Carey Ann D.
AU - Dantas, Gautam
AU - Kwon, Jennie H.
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2021/6/15
Y1 - 2021/6/15
N2 - This review will consider the gut as a reservoir for antimicrobial resistance, colonization resistance, and how disruption of the microbiome can lead to colonization by pathogenic organisms. There is a focus on the gut as a reservoir for β-lactam and plasmid-mediated quinolone resistance. Finally, the role of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome is discussed, along with the potential for future microbiome-directed methods to detect and prevent infection.
AB - This review will consider the gut as a reservoir for antimicrobial resistance, colonization resistance, and how disruption of the microbiome can lead to colonization by pathogenic organisms. There is a focus on the gut as a reservoir for β-lactam and plasmid-mediated quinolone resistance. Finally, the role of functional metagenomics and long-read sequencing technologies to detect and understand antimicrobial resistance genes within the gut microbiome is discussed, along with the potential for future microbiome-directed methods to detect and prevent infection.
KW - Antibiotic resistance
KW - Antimicrobial resistance
KW - Microbiome
KW - Resistome
UR - http://www.scopus.com/inward/record.url?scp=85108387200&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiaa497
DO - 10.1093/infdis/jiaa497
M3 - Review article
C2 - 33326581
AN - SCOPUS:85108387200
SN - 0022-1899
VL - 223
SP - S209-S213
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -