Abstract
The GGA (Golgi-localized, γ-ear containing, ADP-ribosylation factor binding) family of multidomain coat proteins was first described in the year 2000. They are now known to occupy a central position in the trafficking of the mannose 6-phosphate receptors and other cargo molecules from the trans-Golgi network to the endosome/lysosome system. This review covers the recent structural and cell biological studies that have provided mechanistic insights into the function of the GGAs in mannose 6-phosphate receptor trafficking.
Original language | English |
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Pages (from-to) | 257-262 |
Number of pages | 6 |
Journal | European journal of cell biology |
Volume | 83 |
Issue number | 6 |
DOIs | |
State | Published - Jul 2004 |