TY - JOUR
T1 - The genomics of heart failure
T2 - design and rationale of the HERMES consortium
AU - Regeneron Genetics Center
AU - Lumbers, R. Thomas
AU - Shah, Sonia
AU - Lin, Honghuang
AU - Czuba, Tomasz
AU - Henry, Albert
AU - Swerdlow, Daniel I.
AU - Mälarstig, Anders
AU - Andersson, Charlotte
AU - Verweij, Niek
AU - Holmes, Michael V.
AU - Ärnlöv, Johan
AU - Svensson, Per
AU - Hemingway, Harry
AU - Sallah, Neneh
AU - Almgren, Peter
AU - Aragam, Krishna G.
AU - Asselin, Geraldine
AU - Backman, Joshua D.
AU - Biggs, Mary L.
AU - Bloom, Heather L.
AU - Boersma, Eric
AU - Brandimarto, Jeffrey
AU - Brown, Michael R.
AU - Brunner-La Rocca, Hans Peter
AU - Carey, David J.
AU - Chaffin, Mark D.
AU - Chasman, Daniel I.
AU - Chazara, Olympe
AU - Chen, Xing
AU - Chen, Xu
AU - Chung, Jonathan H.
AU - Chutkow, William
AU - Cleland, John G.F.
AU - Cook, James P.
AU - de Denus, Simon
AU - Dehghan, Abbas
AU - Delgado, Graciela E.
AU - Denaxas, Spiros
AU - Doney, Alexander S.
AU - Dörr, Marcus
AU - Dudley, Samuel C.
AU - Engström, Gunnar
AU - Esko, Tõnu
AU - Fatemifar, Ghazaleh
AU - Felix, Stephan B.
AU - Finan, Chris
AU - Ford, Ian
AU - Fougerousse, Francoise
AU - Fouodjio, René
AU - Ghanbari, Mohsen
AU - Ghasemi, Sahar
AU - Giedraitis, Vilmantas
AU - Giulianini, Franco
AU - Gottdiener, John S.
AU - Gross, Stefan
AU - Guðbjartsson, Daníel F.
AU - Gui, Hongsheng
AU - Gutmann, Rebecca
AU - Haggerty, Christopher M.
AU - van der Harst, Pim
AU - Hedman, Åsa K.
AU - Helgadottir, Anna
AU - Hillege, Hans
AU - Hyde, Craig L.
AU - Jacob, Jaison
AU - Jukema, J. Wouter
AU - Kamanu, Frederick
AU - Kardys, Isabella
AU - Kavousi, Maryam
AU - Khaw, Kay Tee
AU - Kleber, Marcus E.
AU - Køber, Lars
AU - Koekemoer, Andrea
AU - Kraus, Bill
AU - Kuchenbaecker, Karoline
AU - Langenberg, Claudia
AU - Lind, Lars
AU - Lindgren, Cecilia M.
AU - London, Barry
AU - Lotta, Luca A.
AU - Lovering, Ruth C.
AU - Luan, Jian'an
AU - Magnusson, Patrik
AU - Mahajan, Anubha
AU - Mann, Douglas
AU - Margulies, Kenneth B.
AU - Marston, Nicholas A.
AU - März, Winfried
AU - McMurray, John J.V.
AU - Melander, Olle
AU - Melloni, Giorgio
AU - Mordi, Ify R.
AU - Morley, Michael P.
AU - Morris, Andrew D.
AU - Morris, Andrew P.
AU - Morrison, Alanna C.
AU - Nagle, Michael W.
AU - Nelson, Christopher P.
AU - Newton-Cheh, Christopher
AU - Niessner, Alexander
AU - Niiranen, Teemu
AU - Nowak, Christoph
AU - O'Donoghue, Michelle L.
AU - Owens, Anjali T.
AU - Palmer, Colin N.A.
AU - Paré, Guillaume
AU - Perola, Markus
AU - Perreault, Louis Philippe Lemieux
AU - Portilla-Fernandez, Eliana
AU - Psaty, Bruce M.
AU - Rice, Kenneth M.
AU - Ridker, Paul M.
AU - Romaine, Simon P.R.
AU - Roselli, Carolina
AU - Rotter, Jerome I.
AU - Ruff, Christian T.
AU - Sabatine, Marc S.
AU - Salo, Perttu
AU - Salomaa, Veikko
AU - van Setten, Jessica
AU - Shalaby, Alaa A.
AU - Smelser, Diane T.
AU - Smith, Nicholas L.
AU - Stefansson, Kari
AU - Stender, Steen
AU - Stott, David J.
AU - Sveinbjörnsson, Garðar
AU - Tammesoo, Mari Liis
AU - Tardif, Jean Claude
AU - Taylor, Kent D.
AU - Teder-Laving, Maris
AU - Teumer, Alexander
AU - Thorgeirsson, Guðmundur
AU - Thorsteinsdottir, Unnur
AU - Torp-Pedersen, Christian
AU - Trompet, Stella
AU - Tuckwell, Danny
AU - Tyl, Benoit
AU - Uitterlinden, Andre G.
AU - Vaura, Felix
AU - Veluchamy, Abirami
AU - Visscher, Peter M.
AU - Völker, Uwe
AU - Voors, Adriaan A.
AU - Wang, Xiaosong
AU - Wareham, Nicholas J.
AU - Weeke, Peter E.
AU - Weiss, Raul
AU - White, Harvey D.
AU - Wiggins, Kerri L.
AU - Xing, Heming
AU - Yang, Jian
AU - Yang, Yifan
AU - Yerges-Armstrong, Laura M.
AU - Yu, Bing
AU - Zannad, Faiez
AU - Zhao, Faye
AU - Wilk, Jemma B.
AU - Holm, Hilma
AU - Sattar, Naveed
AU - Lubitz, Steven A.
AU - Lanfear, David E.
AU - Shah, Svati
AU - Dunn, Michael E.
AU - Wells, Quinn S.
AU - Asselbergs, Folkert W.
AU - Hingorani, Aroon D.
AU - Dubé, Marie Pierre
AU - Samani, Nilesh J.
AU - Lang, Chim C.
AU - Cappola, Thomas P.
AU - Ellinor, Patrick T.
AU - Vasan, Ramachandran S.
AU - Smith, J. Gustav
N1 - Publisher Copyright:
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
PY - 2021/12
Y1 - 2021/12
N2 - Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
AB - Aims: The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium aims to identify the genomic and molecular basis of heart failure. Methods and results: The consortium currently includes 51 studies from 11 countries, including 68 157 heart failure cases and 949 888 controls, with data on heart failure events and prognosis. All studies collected biological samples and performed genome-wide genotyping of common genetic variants. The enrolment of subjects into participating studies ranged from 1948 to the present day, and the median follow-up following heart failure diagnosis ranged from 2 to 116 months. Forty-nine of 51 individual studies enrolled participants of both sexes; in these studies, participants with heart failure were predominantly male (34–90%). The mean age at diagnosis or ascertainment across all studies ranged from 54 to 84 years. Based on the aggregate sample, we estimated 80% power to genetic variant associations with risk of heart failure with an odds ratio of ≥1.10 for common variants (allele frequency ≥ 0.05) and ≥1.20 for low-frequency variants (allele frequency 0.01–0.05) at P < 5 × 10−8 under an additive genetic model. Conclusions: HERMES is a global collaboration aiming to (i) identify the genetic determinants of heart failure; (ii) generate insights into the causal pathways leading to heart failure and enable genetic approaches to target prioritization; and (iii) develop genomic tools for disease stratification and risk prediction.
UR - http://www.scopus.com/inward/record.url?scp=85114632006&partnerID=8YFLogxK
U2 - 10.1002/ehf2.13517
DO - 10.1002/ehf2.13517
M3 - Article
C2 - 34480422
AN - SCOPUS:85114632006
SN - 2055-5822
VL - 8
SP - 5531
EP - 5541
JO - ESC Heart Failure
JF - ESC Heart Failure
IS - 6
ER -