The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation

Karin J.H. Verweij; Anna A.E. Vinkhuyzen; Beben Benyamin; Michael T. Lynskey; Lydia Quaye; Arpana Agrawal; Scott D. Gordon; Grant W. Montgomery; Pamela A.F. Madden; Andrew C. Heath; Timothy D. Spector; Nicholas G. Martin; Sarah E. Medland

doi:10.1111/j.1369-1600.2012.00478.x

The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation

Karin J.H. Verweij, Anna A.E. Vinkhuyzen, Beben Benyamin, Michael T. Lynskey, Lydia Quaye, Arpana Agrawal, Scott D. Gordon, Grant W. Montgomery, Pamela A.F. Madden, Andrew C. Heath, Timothy D. Spector, Nicholas G. Martin, Sarah E. Medland

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44 Scopus citations

Abstract

While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.

Original language	English
Pages (from-to)	846-850
Number of pages	5
Journal	Addiction Biology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1111/j.1369-1600.2012.00478.x
State	Published - Sep 2013

Keywords

Association
cannabis
genetics
heritability

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Verweij, K. J. H., Vinkhuyzen, A. A. E., Benyamin, B., Lynskey, M. T., Quaye, L., Agrawal, A., Gordon, S. D., Montgomery, G. W., Madden, P. A. F., Heath, A. C., Spector, T. D., Martin, N. G., & Medland, S. E. (2013). The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation. Addiction Biology, 18(5), 846-850. https://doi.org/10.1111/j.1369-1600.2012.00478.x

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title = "The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation",

abstract = "While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.",

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author = "Verweij, {Karin J.H.} and Vinkhuyzen, {Anna A.E.} and Beben Benyamin and Lynskey, {Michael T.} and Lydia Quaye and Arpana Agrawal and Gordon, {Scott D.} and Montgomery, {Grant W.} and Madden, {Pamela A.F.} and Heath, {Andrew C.} and Spector, {Timothy D.} and Martin, {Nicholas G.} and Medland, {Sarah E.}",

year = "2013",

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doi = "10.1111/j.1369-1600.2012.00478.x",

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Verweij, KJH, Vinkhuyzen, AAE, Benyamin, B, Lynskey, MT, Quaye, L, Agrawal, A, Gordon, SD, Montgomery, GW, Madden, PAF , Heath, AC, Spector, TD, Martin, NG & Medland, SE 2013, 'The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation', Addiction Biology, vol. 18, no. 5, pp. 846-850. https://doi.org/10.1111/j.1369-1600.2012.00478.x

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AU - Verweij, Karin J.H.

AU - Vinkhuyzen, Anna A.E.

AU - Benyamin, Beben

AU - Lynskey, Michael T.

AU - Quaye, Lydia

AU - Agrawal, Arpana

AU - Gordon, Scott D.

AU - Montgomery, Grant W.

AU - Madden, Pamela A.F.

AU - Heath, Andrew C.

AU - Spector, Timothy D.

AU - Martin, Nicholas G.

AU - Medland, Sarah E.

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N2 - While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.

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The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation

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