The genetic aetiology of cannabis use initiation: A meta-analysis of genome-wide association studies and a SNP-based heritability estimation

Karin J.H. Verweij, Anna A.E. Vinkhuyzen, Beben Benyamin, Michael T. Lynskey, Lydia Quaye, Arpana Agrawal, Scott D. Gordon, Grant W. Montgomery, Pamela A.F. Madden, Andrew C. Heath, Timothy D. Spector, Nicholas G. Martin, Sarah E. Medland

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use.

Original languageEnglish
Pages (from-to)846-850
Number of pages5
JournalAddiction Biology
Volume18
Issue number5
DOIs
StatePublished - Sep 2013

Keywords

  • Association
  • cannabis
  • genetics
  • heritability

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