TY - JOUR
T1 - The GDNF family ligands and receptors - Implications for neural development
AU - Baloh, Robert H.
AU - Enomoto, Hideki
AU - Johnson, Eugene M.
AU - Milbrandt, Jeffrey
N1 - Funding Information:
We thank all members of the Milbrandt and Johnson labs for invaluable discussions regarding the ideas and issues presented here. The authors are supported by National Institutes of Health grants R01 AG13729 and R01 AG13730.
PY - 2000/2/1
Y1 - 2000/2/1
N2 - The glial cell line derived neurotrophic factor (GDNF) family has recently been expanded to include four members, and the interactions between these neurotrophic factors and their unique receptor system is now beginning to be understood. Furthermore, analysis of mice lacking the genes for GDNF, neurturin, and their related receptors has confirmed the importance of these factors in neurodevelopment. The results of such analyses reveal numerous similarities and potential overlaps in the way the GDNF and the nerve growth factor (NGF) families regulate development of the peripheral nervous system.
AB - The glial cell line derived neurotrophic factor (GDNF) family has recently been expanded to include four members, and the interactions between these neurotrophic factors and their unique receptor system is now beginning to be understood. Furthermore, analysis of mice lacking the genes for GDNF, neurturin, and their related receptors has confirmed the importance of these factors in neurodevelopment. The results of such analyses reveal numerous similarities and potential overlaps in the way the GDNF and the nerve growth factor (NGF) families regulate development of the peripheral nervous system.
UR - http://www.scopus.com/inward/record.url?scp=0033964411&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(99)00048-3
DO - 10.1016/S0959-4388(99)00048-3
M3 - Review article
C2 - 10679429
AN - SCOPUS:0033964411
SN - 0959-4388
VL - 10
SP - 103
EP - 110
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -