The gastric mucosa: Development and differentiation

Shradha Khurana, Jason C. Mills

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations


The development and differentiation of the gastric mucosa are controlled by a complex interplay of signaling proteins and transcriptional regulators. This process is complicated by the fact that the stomach is derived from two germ layers, the endoderm and the mesoderm, with the first giving rise to the mature epithelium and the latter contributing the smooth muscle required for peristalsis. Reciprocal epithelialmesenchymal interactions dictate the formation of the stomach during fetal development, and also contribute to its continuous regeneration and differentiation throughout adult life. In this chapter, we discuss the discoveries that have been made in different model systems, from zebrafish to human, which show that the Hedgehog, Wnt, Notch, bone morphogenetic protein, and fibroblast growth factor (FGF) signaling systems play essential roles during various stages of stomach development.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Number of pages23
StatePublished - 2010

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173


  • Anteroposterior axis
  • Gastric epithelial differentiation
  • Gastric epithelial homeostasis
  • Morphogens
  • Postnatal gastric development
  • Stomach specification


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