TY - JOUR
T1 - The Gastric Cancer Registry
T2 - A Genomic Translational Resource for Multidisciplinary Research in Gastric Cancer
AU - Almeda, Alison F.
AU - Grimes, Susan M.
AU - Lee, Ho Joon
AU - Greer, Stephanie
AU - Shin, Gi Won
AU - McNamara, Madeline
AU - Hooker, Anna C.
AU - Arce, Maya M.
AU - Kubit, Matthew
AU - Schauer, Marie C.
AU - Van Hummelen, Paul
AU - Ma, Cindy
AU - Mills, Meredith A.
AU - Huang, Robert J.
AU - Hwang, Joo Ha
AU - Amieva, Manuel R.
AU - Han, Summer S.
AU - Ford, James M.
AU - Ji, Hanlee P.
N1 - Publisher Copyright:
©2022 American Association for Cancer Research.
PY - 2022/9
Y1 - 2022/9
N2 - Background: Gastric cancer is a leading cause of cancer morResults: From 2011 to 2021, 567 individuals registered and bidity and mortality. Developing information systems which intereturned the clinical questionnaire. For this cohort 65% had a grate clinical and genomic data may accelerate discoveries to personal history of gastric cancer, 36% reported a family history improve cancer prevention, detection, and treatment. To support of gastric cancer, and 14% had a germline CDH1 mutation. 89 translational research in gastric cancer, we developed the Gastric patients with gastric cancer provided tumor samples. For the initial Cancer Registry (GCR), a North American repository of clinical and study, 41 tumors were sequenced using next-generation sequencing. cancer genomics data. The data was analyzed for cancer mutations, copy-number variaMethods: Participants self-enrolled online. Entry criteria tions, gene expression, microbiome, neoantigens, immune infilinto the GCR included the following: (i) diagnosis of gastric trates, and other features. We developed a searchable, web-based cancer, (ii) history of gastric cancer in a first- or second-degree interface (the GCR Genome Explorer) to enable researchers’ access relative, or (iii) known germline mutation in the gene CDH1. to these datasets. Participants provided demographic and clinical information Conclusions: The GCR is a unique, North American gastric through a detailed survey. Some participants provided speci-cancer registry which integrates clinical and genomic annotation. mens of saliva and tumor samples. Tumor samples underwent Impact: Available for researchers through an open access, web-exome sequencing, whole-genome sequencing, and transcripbased explorer, the GCR Genome Explorer will accelerate collabtome sequencing. orative gastric cancer research across the United States and world.
AB - Background: Gastric cancer is a leading cause of cancer morResults: From 2011 to 2021, 567 individuals registered and bidity and mortality. Developing information systems which intereturned the clinical questionnaire. For this cohort 65% had a grate clinical and genomic data may accelerate discoveries to personal history of gastric cancer, 36% reported a family history improve cancer prevention, detection, and treatment. To support of gastric cancer, and 14% had a germline CDH1 mutation. 89 translational research in gastric cancer, we developed the Gastric patients with gastric cancer provided tumor samples. For the initial Cancer Registry (GCR), a North American repository of clinical and study, 41 tumors were sequenced using next-generation sequencing. cancer genomics data. The data was analyzed for cancer mutations, copy-number variaMethods: Participants self-enrolled online. Entry criteria tions, gene expression, microbiome, neoantigens, immune infilinto the GCR included the following: (i) diagnosis of gastric trates, and other features. We developed a searchable, web-based cancer, (ii) history of gastric cancer in a first- or second-degree interface (the GCR Genome Explorer) to enable researchers’ access relative, or (iii) known germline mutation in the gene CDH1. to these datasets. Participants provided demographic and clinical information Conclusions: The GCR is a unique, North American gastric through a detailed survey. Some participants provided speci-cancer registry which integrates clinical and genomic annotation. mens of saliva and tumor samples. Tumor samples underwent Impact: Available for researchers through an open access, web-exome sequencing, whole-genome sequencing, and transcripbased explorer, the GCR Genome Explorer will accelerate collabtome sequencing. orative gastric cancer research across the United States and world.
UR - http://www.scopus.com/inward/record.url?scp=85137136092&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-22-0308
DO - 10.1158/1055-9965.EPI-22-0308
M3 - Article
C2 - 35771165
AN - SCOPUS:85137136092
SN - 1055-9965
VL - 31
SP - 1693
EP - 1700
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 9
ER -