The G-protein βγ complex

N. Gautam; G. B. Downes; K. Yan; O. Kisselev

doi:10.1016/S0898-6568(98)00006-0

The G-protein βγ complex

N. Gautam
, G. B. Downes
, K. Yan
, O. Kisselev

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

Original language	English
Pages (from-to)	447-455
Number of pages	9
Journal	Cellular Signalling
Volume	10
Issue number	7
DOIs	https://doi.org/10.1016/S0898-6568(98)00006-0
State	Published - Jul 1998

Keywords

G-protein subunits
Protein families
Protein interactions

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10.1016/S0898-6568(98)00006-0

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title = "The G-protein βγ complex",

abstract = "The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.",

keywords = "G-protein subunits, Protein families, Protein interactions",

author = "N. Gautam and Downes, \{G. B.\} and K. Yan and O. Kisselev",

note = "Funding Information: Work in the authors{\textquoteright} laboratory was supported by the National Institutes of Health. N. G. is an Established Investigator of the American Heart Association.",

year = "1998",

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T1 - The G-protein βγ complex

AU - Gautam, N.

AU - Downes, G. B.

AU - Yan, K.

AU - Kisselev, O.

N1 - Funding Information: Work in the authors’ laboratory was supported by the National Institutes of Health. N. G. is an Established Investigator of the American Heart Association.

PY - 1998/7

Y1 - 1998/7

N2 - The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

AB - The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

KW - G-protein subunits

KW - Protein families

KW - Protein interactions

UR - https://www.scopus.com/pages/publications/0031593726

U2 - 10.1016/S0898-6568(98)00006-0

DO - 10.1016/S0898-6568(98)00006-0

M3 - Article

C2 - 9754712

AN - SCOPUS:0031593726

SN - 0898-6568

VL - 10

SP - 447

EP - 455

JO - Cellular Signalling

JF - Cellular Signalling

IS - 7

ER -

The G-protein βγ complex

Abstract

Keywords

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