The G-protein βγ complex

N. Gautam, G. B. Downes, K. Yan, O. Kisselev

Research output: Contribution to journalArticlepeer-review

154 Scopus citations


The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalCellular Signalling
Issue number7
StatePublished - Jul 1998


  • G-protein subunits
  • Protein families
  • Protein interactions


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