The G-protein βγ complex

N. Gautam, G. B. Downes, K. Yan, O. Kisselev

Research output: Contribution to journalArticle

148 Scopus citations

Abstract

The vast majority of signalling pathways in mammalian cells are mediated by heterotrimeric (αβγ) G Proteins. Reviewed here is regulation of signal transduction by the βγ complex at different protein interfaces: subunit-subunit, receptor-G protein and G protein-effector. The role of diverse β and γ subunit types in achieving specificity in signalling and potentially unidentified functions for these subunits also are discussed.

Original languageEnglish
Pages (from-to)447-455
Number of pages9
JournalCellular Signalling
Volume10
Issue number7
DOIs
StatePublished - Jul 1998

Keywords

  • G-protein subunits
  • Protein families
  • Protein interactions

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    Gautam, N., Downes, G. B., Yan, K., & Kisselev, O. (1998). The G-protein βγ complex. Cellular Signalling, 10(7), 447-455. https://doi.org/10.1016/S0898-6568(98)00006-0