The function of PS integrins in Drosophila wing morphogenesis

M. Wilcox, A. DiAntonio, M. Leptin

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Integrins are found on many cell types during the development of most organisms. In Drosophila their functions can be analysed genetically. An analysis of lethal mutations in a PS integrin gene showed that the integrins were required for muscle attachment and for certain cell sheet migrations during embryogenesis. In this apper we use viable mutations in integrin component genes to look at integrin function in the later stages of development of one adult structure, the wing. We show that two known viable mutations, one which has its primary effect on the fly's escape response, the other on wing morphogenesis, are mutations in the β and PS2α subunits, respectively, of the PS integrins. The mutation non-jumper (mys(nj42)) in the β subunit leads to wasting of the thoracic jump muscles. Flies in which the dosage of this allele is reduced (and no wildtype copy is present) show defects also in wing morphogenesis. The two surfaces of the wing fail to connect properly, resulting in 'blistering' of the wing and the formation of extra crossveins. The mutation in the gene for the PS2α integrin subunit, inflated, also leads to a failure in wing surface apposition and consequent wing blistering. When the two mutations are combined, the mutant phenotype is greatly enhanced. Thus, one of the roles of the PS integrins in late Drosophila development is to ensure the correct apposition and patterning of the wing epithelia.

Original languageEnglish
Pages (from-to)891-897
Number of pages7
JournalDevelopment
Volume107
Issue number4
StatePublished - Dec 1 1989
Externally publishedYes

Keywords

  • Drosophila morphogenesis
  • cell adhesion
  • integrin mutants

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