TY - JOUR
T1 - The fit older adult with acute myeloid leukemia
T2 - clinical challenges to providing evidence-based frontline treatment
AU - Abedin, Sameem
AU - Uy, Geoffrey L.
AU - Michaelis, Laura C.
N1 - Publisher Copyright:
© 2025 American Society of Hematology
PY - 2025/6/12
Y1 - 2025/6/12
N2 - Recent advances in acute myeloid leukemia (AML) come from studies investigating older adults aged <60 years, those aged ≥75 years, or less fit adults. Uncertainty exists for the management of otherwise healthy adults with AML in their 60s and 70s, which also represents a significant proportion of AML cases. We discuss current considerations in older, fit adults with AML, including determination of fitness, factors beyond fitness that should be assessed, and challenges and innovations to improve patient outcomes.
AB - Recent advances in acute myeloid leukemia (AML) come from studies investigating older adults aged <60 years, those aged ≥75 years, or less fit adults. Uncertainty exists for the management of otherwise healthy adults with AML in their 60s and 70s, which also represents a significant proportion of AML cases. We discuss current considerations in older, fit adults with AML, including determination of fitness, factors beyond fitness that should be assessed, and challenges and innovations to improve patient outcomes.
UR - https://www.scopus.com/pages/publications/85218861926
U2 - 10.1182/blood.2024026004
DO - 10.1182/blood.2024026004
M3 - Review article
C2 - 39854694
AN - SCOPUS:85218861926
SN - 0006-4971
VL - 145
SP - 2840
EP - 2846
JO - Blood
JF - Blood
IS - 24
ER -