TY - JOUR
T1 - The fine-scale functional correlation of striate cortex in sighted and blind people
AU - Butt, Omar H.
AU - Benson, Noah C.
AU - Datta, Ritobrato
AU - Aguirre, Geoffrey K.
PY - 2013
Y1 - 2013
N2 - To what extent are spontaneous neural signals within striate cortex organized by vision? We examined the fine-scale pattern of striate cortex correlations within and between hemispheres in rest-state BOLD fMRI data from sighted and blind people. In the sighted, we find that corticocortico correlation is well modeled as a Gaussian point-spread function across millimeters of striate cortical surface, rather than degrees of visual angle. Blindness produces a subtle change in the pattern of fine-scale striate correlations between hemispheres. Across participants blind before the age of 18, the degree of pattern alteration covaries with the strength of long-range correlation between left striate cortex and Broca's area. This suggests that early blindness exchanges local, vision-driven pattern synchrony of the striate cortices for long-range functional correlations potentially related to cross-modal representation.
AB - To what extent are spontaneous neural signals within striate cortex organized by vision? We examined the fine-scale pattern of striate cortex correlations within and between hemispheres in rest-state BOLD fMRI data from sighted and blind people. In the sighted, we find that corticocortico correlation is well modeled as a Gaussian point-spread function across millimeters of striate cortical surface, rather than degrees of visual angle. Blindness produces a subtle change in the pattern of fine-scale striate correlations between hemispheres. Across participants blind before the age of 18, the degree of pattern alteration covaries with the strength of long-range correlation between left striate cortex and Broca's area. This suggests that early blindness exchanges local, vision-driven pattern synchrony of the striate cortices for long-range functional correlations potentially related to cross-modal representation.
UR - http://www.scopus.com/inward/record.url?scp=84885160408&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.0363-13.2013
DO - 10.1523/JNEUROSCI.0363-13.2013
M3 - Article
C2 - 24107953
AN - SCOPUS:84885160408
SN - 0270-6474
VL - 33
SP - 16209
EP - 16219
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 41
ER -