The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study

Ornnicha Sathitakorn, Kittiya Jantarathaneewat, David J. Weber, David K. Warren, Sira Nanthapisal, Sasinuch Rutjanawech, Piyaporn Apisarnthanarak, Anucha Apisarnthanarak

Research output: Contribution to journalArticlepeer-review

Abstract

Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalAmerican Journal of Infection Control
Volume50
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • Antibiotic stewardship
  • COVID-19
  • Inappropriate antibiotic use
  • Intensive care
  • Strategy

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