TY - JOUR
T1 - The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients
T2 - A pilot study
AU - Sathitakorn, Ornnicha
AU - Jantarathaneewat, Kittiya
AU - Weber, David J.
AU - Warren, David K.
AU - Nanthapisal, Sira
AU - Rutjanawech, Sasinuch
AU - Apisarnthanarak, Piyaporn
AU - Apisarnthanarak, Anucha
N1 - Funding Information:
Funding: This study was supported by Faculty of Medicine, Thammasat University Research Fund.
Publisher Copyright:
© 2022 Association for Professionals in Infection Control and Epidemiology, Inc.
PY - 2022/5
Y1 - 2022/5
N2 - Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).
AB - Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).
KW - Antibiotic stewardship
KW - COVID-19
KW - Inappropriate antibiotic use
KW - Intensive care
KW - Strategy
UR - http://www.scopus.com/inward/record.url?scp=85127355725&partnerID=8YFLogxK
U2 - 10.1016/j.ajic.2022.01.030
DO - 10.1016/j.ajic.2022.01.030
M3 - Article
C2 - 35158008
AN - SCOPUS:85127355725
VL - 50
SP - 581
EP - 584
JO - American Journal of Infection Control
JF - American Journal of Infection Control
SN - 0196-6553
IS - 5
ER -