The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study

Ornnicha Sathitakorn; Kittiya Jantarathaneewat; David J. Weber; David K. Warren; Sira Nanthapisal; Sasinuch Rutjanawech; Piyaporn Apisarnthanarak; Anucha Apisarnthanarak

doi:10.1016/j.ajic.2022.01.030

The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study

Ornnicha Sathitakorn, Kittiya Jantarathaneewat, David J. Weber, David K. Warren, Sira Nanthapisal, Sasinuch Rutjanawech, Piyaporn Apisarnthanarak, Anucha Apisarnthanarak

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10 Scopus citations

Abstract

Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	American Journal of Infection Control
Volume	50
Issue number	5
DOIs	https://doi.org/10.1016/j.ajic.2022.01.030
State	Published - May 2022

Keywords

Antibiotic stewardship
COVID-19
Inappropriate antibiotic use
Intensive care
Strategy

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Sathitakorn, O., Jantarathaneewat, K., Weber, D. J., Warren, D. K., Nanthapisal, S., Rutjanawech, S., Apisarnthanarak, P., & Apisarnthanarak, A. (2022). The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study. American Journal of Infection Control, 50(5), 581-584. https://doi.org/10.1016/j.ajic.2022.01.030

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title = "The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study",

abstract = "Antibiotics have been extensively used in COVID-19 patients without a clear indication. We conducted a study to evaluate the feasibility of procalcitonin along with the “Clinical Pulmonary for Infection Score” (CPIS) as a strategy to reduce inappropriate antibiotic use. Using procalcitonin and CPIS score (PCT-CPIS) successfully reduced inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients (45% vs 100%; P <.01). Compared to “non PCT-CPIS” group, “PCT-CPIS” group was associated with a reduction in the incidence of multidrug-resistant organisms and invasive fungal infections (18.3% vs 36.7%; P =.03), shorter antibiotic duration (2 days vs 7 days; P <.01) and length of hospital stay (10 days vs 16 days; P <.01).",

keywords = "Antibiotic stewardship, COVID-19, Inappropriate antibiotic use, Intensive care, Strategy",

author = "Ornnicha Sathitakorn and Kittiya Jantarathaneewat and Weber, {David J.} and Warren, {David K.} and Sira Nanthapisal and Sasinuch Rutjanawech and Piyaporn Apisarnthanarak and Anucha Apisarnthanarak",

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Sathitakorn, O, Jantarathaneewat, K, Weber, DJ, Warren, DK, Nanthapisal, S, Rutjanawech, S, Apisarnthanarak, P & Apisarnthanarak, A 2022, 'The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study', American Journal of Infection Control, vol. 50, no. 5, pp. 581-584. https://doi.org/10.1016/j.ajic.2022.01.030

The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study. / Sathitakorn, Ornnicha; Jantarathaneewat, Kittiya; Weber, David J. et al.
In: American Journal of Infection Control, Vol. 50, No. 5, 05.2022, p. 581-584.

Research output: Contribution to journal › Article › peer-review

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AU - Sathitakorn, Ornnicha

AU - Jantarathaneewat, Kittiya

AU - Weber, David J.

AU - Warren, David K.

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AU - Rutjanawech, Sasinuch

AU - Apisarnthanarak, Piyaporn

AU - Apisarnthanarak, Anucha

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The feasibility of procalcitonin and CPIS score to reduce inappropriate antibiotics use among severe-critically ill COVID-19 pneumonia patients: A pilot study

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Keywords

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