The fate of monocytes in atherosclerosis

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Monocytes are the primary inflammatory cell type that infiltrates early atherosclerotic plaques. Their recruitment into plaques drives disease progression. Disease interventions that target monocytes could act at several points: alteration in the phenotype of circulating monocyte subpopulations; reduced recruitment of monocytes into plaques; alterations in the survival of monocyte-derived cells in atherosclerosis; and promotion of migratory egress from plaques to bring about resolution of the plaque inflammatory response. All of these points of intervention will be briefly discussed in this article.

Original languageEnglish
Pages (from-to)28-30
Number of pages3
JournalJournal of Thrombosis and Haemostasis
Volume7
Issue numberSUPPL. 1
DOIs
StatePublished - Aug 4 2009
Externally publishedYes

Keywords

  • Chemotaxis
  • Chronic inflammation
  • Dendritic cell
  • Macrophage

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