The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation

Georgi L. Lukov, Lara Rossi, George P. Souroullas, Rui Mao, Margaret A. Goodell

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Abstract

This study investigates the function of the lymphoblastic leukemia gene, Lyl1 in the hematopoietic system and its oncogenic potential in the development of leukemia. Overexpression of Lyl1 in mouse bone marrow cells caused T-cell increase in the peripheral blood and expansion of the hematopoietic progenitors in culture and in the bone marrow. These observations were the result of increased proliferation and suppressed apoptosis of the progenitor cells caused by the Lyl1-overexpression. Our studies present substantial evidence supporting the secondary, pro-leukemic effect of Lyl1 in early hematopoietic progenitors with the potential to cause expansion of malignant cells with a stem/early progenitor-like phenotype.

Original languageEnglish
Pages (from-to)405-412
Number of pages8
JournalLeukemia Research
Volume35
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • AML
  • Apoptosis
  • Hematopoietic progenitors
  • Leukemia
  • Lyl1
  • T-cell ALL
  • T-cells

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