The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation

Georgi L. Lukov; Lara Rossi; George P. Souroullas; Rui Mao; Margaret A. Goodell

doi:10.1016/j.leukres.2010.07.023

The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation

Georgi L. Lukov, Lara Rossi, George P. Souroullas, Rui Mao, Margaret A. Goodell

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Abstract

This study investigates the function of the lymphoblastic leukemia gene, Lyl1 in the hematopoietic system and its oncogenic potential in the development of leukemia. Overexpression of Lyl1 in mouse bone marrow cells caused T-cell increase in the peripheral blood and expansion of the hematopoietic progenitors in culture and in the bone marrow. These observations were the result of increased proliferation and suppressed apoptosis of the progenitor cells caused by the Lyl1-overexpression. Our studies present substantial evidence supporting the secondary, pro-leukemic effect of Lyl1 in early hematopoietic progenitors with the potential to cause expansion of malignant cells with a stem/early progenitor-like phenotype.

Original language	English
Pages (from-to)	405-412
Number of pages	8
Journal	Leukemia Research
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2010.07.023
State	Published - Mar 2011

Keywords

AML
Apoptosis
Hematopoietic progenitors
Leukemia
Lyl1
T-cell ALL
T-cells

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10.1016/j.leukres.2010.07.023

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title = "The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation",

abstract = "This study investigates the function of the lymphoblastic leukemia gene, Lyl1 in the hematopoietic system and its oncogenic potential in the development of leukemia. Overexpression of Lyl1 in mouse bone marrow cells caused T-cell increase in the peripheral blood and expansion of the hematopoietic progenitors in culture and in the bone marrow. These observations were the result of increased proliferation and suppressed apoptosis of the progenitor cells caused by the Lyl1-overexpression. Our studies present substantial evidence supporting the secondary, pro-leukemic effect of Lyl1 in early hematopoietic progenitors with the potential to cause expansion of malignant cells with a stem/early progenitor-like phenotype.",

keywords = "AML, Apoptosis, Hematopoietic progenitors, Leukemia, Lyl1, T-cell ALL, T-cells",

author = "Lukov, {Georgi L.} and Lara Rossi and Souroullas, {George P.} and Rui Mao and Goodell, {Margaret A.}",

note = "Funding Information: We would like to extend our appreciation to Fabian Zohren and the rest of our colleagues from the Goodell lab for the helpful discussions and support throughout this study. We also like to thank Dr. Brendan Lee from Baylor College of Medicine for donating a plasmid copy of NOTCH1. The financial support for this work was provided by NIH grants DK58192 , HL081007 , and Ellison Foundation grant number AGSS1787 . ",

year = "2011",

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volume = "35",

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T1 - The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation

AU - Lukov, Georgi L.

AU - Rossi, Lara

AU - Souroullas, George P.

AU - Mao, Rui

AU - Goodell, Margaret A.

N1 - Funding Information: We would like to extend our appreciation to Fabian Zohren and the rest of our colleagues from the Goodell lab for the helpful discussions and support throughout this study. We also like to thank Dr. Brendan Lee from Baylor College of Medicine for donating a plasmid copy of NOTCH1. The financial support for this work was provided by NIH grants DK58192 , HL081007 , and Ellison Foundation grant number AGSS1787 .

PY - 2011/3

Y1 - 2011/3

N2 - This study investigates the function of the lymphoblastic leukemia gene, Lyl1 in the hematopoietic system and its oncogenic potential in the development of leukemia. Overexpression of Lyl1 in mouse bone marrow cells caused T-cell increase in the peripheral blood and expansion of the hematopoietic progenitors in culture and in the bone marrow. These observations were the result of increased proliferation and suppressed apoptosis of the progenitor cells caused by the Lyl1-overexpression. Our studies present substantial evidence supporting the secondary, pro-leukemic effect of Lyl1 in early hematopoietic progenitors with the potential to cause expansion of malignant cells with a stem/early progenitor-like phenotype.

AB - This study investigates the function of the lymphoblastic leukemia gene, Lyl1 in the hematopoietic system and its oncogenic potential in the development of leukemia. Overexpression of Lyl1 in mouse bone marrow cells caused T-cell increase in the peripheral blood and expansion of the hematopoietic progenitors in culture and in the bone marrow. These observations were the result of increased proliferation and suppressed apoptosis of the progenitor cells caused by the Lyl1-overexpression. Our studies present substantial evidence supporting the secondary, pro-leukemic effect of Lyl1 in early hematopoietic progenitors with the potential to cause expansion of malignant cells with a stem/early progenitor-like phenotype.

KW - AML

KW - Apoptosis

KW - Hematopoietic progenitors

KW - Leukemia

KW - Lyl1

KW - T-cell ALL

KW - T-cells

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U2 - 10.1016/j.leukres.2010.07.023

DO - 10.1016/j.leukres.2010.07.023

M3 - Article

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AN - SCOPUS:79952104879

SN - 0145-2126

VL - 35

SP - 405

EP - 412

JO - Leukemia Research

JF - Leukemia Research

IS - 3

ER -

The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation

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Keywords

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