The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi

Harrison W. Gabel, Gary Ruvkun

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3′ end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.

Original languageEnglish
Pages (from-to)531-533
Number of pages3
JournalNature Structural and Molecular Biology
Volume15
Issue number5
DOIs
StatePublished - May 1 2008
Externally publishedYes

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