The Evolving Role of Postmastectomy Radiation Therapy

Ashlyn S. Everett; Jennifer F. De Los Santos; Drexell Hunter Boggs

doi:10.1016/j.suc.2018.03.010

The Evolving Role of Postmastectomy Radiation Therapy

Ashlyn S. Everett, Jennifer F. De Los Santos, Drexell Hunter Boggs

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy and discusses open questions that may change the landscape of future breast cancer treatment.

Original language	English
Pages (from-to)	801-817
Number of pages	17
Journal	Surgical Clinics of North America
Volume	98
Issue number	4
DOIs	https://doi.org/10.1016/j.suc.2018.03.010
State	Published - Aug 2018

Keywords

Chest wall
Neoadjuvant chemotherapy
Postmastectomy
Radiation
Regional nodes

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@article{34c8dee2d0ce457895dd36e183d3d476,

title = "The Evolving Role of Postmastectomy Radiation Therapy",

abstract = "Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy and discusses open questions that may change the landscape of future breast cancer treatment.",

keywords = "Chest wall, Neoadjuvant chemotherapy, Postmastectomy, Radiation, Regional nodes",

author = "Everett, {Ashlyn S.} and {De Los Santos}, {Jennifer F.} and Boggs, {Drexell Hunter}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2018",

month = aug,

doi = "10.1016/j.suc.2018.03.010",

language = "English",

volume = "98",

pages = "801--817",

journal = "Surgical Clinics of North America",

issn = "0039-6109",

number = "4",

}

TY - JOUR

T1 - The Evolving Role of Postmastectomy Radiation Therapy

AU - Everett, Ashlyn S.

AU - De Los Santos, Jennifer F.

AU - Boggs, Drexell Hunter

PY - 2018/8

Y1 - 2018/8

N2 - Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy and discusses open questions that may change the landscape of future breast cancer treatment.

AB - Throughout various eras of breast cancer therapy, postmastectomy radiation therapy (PMRT) has played an important role in the treatment of locally advanced breast cancer. PMRT decreases locoregional recurrence and may improve overall survival in patients with tumors over 5 cm or positive lymph nodes. As novel cancer therapies improve survival in breast cancer, the role of radiation therapy is evolving. Individualized recommendations for PMRT dependent on pathologic response after neoadjuvant systemic therapy are under investigation. This review summarizes the role of PMRT during breast cancer therapy and discusses open questions that may change the landscape of future breast cancer treatment.

KW - Chest wall

KW - Neoadjuvant chemotherapy

KW - Postmastectomy

KW - Radiation

KW - Regional nodes

UR - http://www.scopus.com/inward/record.url?scp=85047500233&partnerID=8YFLogxK

U2 - 10.1016/j.suc.2018.03.010

DO - 10.1016/j.suc.2018.03.010

M3 - Review article

C2 - 30005775

AN - SCOPUS:85047500233

SN - 0039-6109

VL - 98

SP - 801

EP - 817

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 4

ER -

The Evolving Role of Postmastectomy Radiation Therapy

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