The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function

V. Michael Holers, Taroh Kinoshita, Hector Molina

Research output: Contribution to journalReview articlepeer-review

117 Scopus citations

Abstract

Despite the fact that the early components of the mouse and human complement cascades are very similar, there are marked differences between the two species in the structure of C3 receptors and the molecules that control homologous lysis. Here, Michael Holers, Taroh Kinoshita and Hector Molina compare and contrast the mouse and human RCA region products and conclude that the receptor and regulatory roles are conserved despite the structural variation.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalImmunology today
Volume13
Issue number6
DOIs
StatePublished - 1992

Fingerprint

Dive into the research topics of 'The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function'. Together they form a unique fingerprint.

Cite this