The evolution of modern theory and therapy for heart failure

Douglas L. Mann

doi:10.1016/j.ppedcard.2014.10.002

The evolution of modern theory and therapy for heart failure

Douglas L. Mann

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Although there have been a number of attempts to develop a unifying theory that explains all aspects of the clinical syndrome of heart failure, none of these conceptual paradigms has withstood the test of time. The foregoing review will discuss four conceptual models that have informed the modern approach to treating heart failure with a reduced ejection fraction, including the cardiorenal model, the cardiocirculatory model, the neurohormonal model and the biomechanical model. The hope is that this historical rendering of the evolution of modern theory and therapy for heart failure will be of some use to the growing field of pediatric heart failure.

Original language	English
Pages (from-to)	9-12
Number of pages	4
Journal	Progress in Pediatric Cardiology
Volume	37
Issue number	1-2
DOIs	https://doi.org/10.1016/j.ppedcard.2014.10.002
State	Published - Dec 1 2014

Keywords

Adrenergic nervous system
Edema
Heart failure
LV remodeling
Neurohormone
Renin angiotensin aldosterone system

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10.1016/j.ppedcard.2014.10.002

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title = "The evolution of modern theory and therapy for heart failure",

abstract = "Although there have been a number of attempts to develop a unifying theory that explains all aspects of the clinical syndrome of heart failure, none of these conceptual paradigms has withstood the test of time. The foregoing review will discuss four conceptual models that have informed the modern approach to treating heart failure with a reduced ejection fraction, including the cardiorenal model, the cardiocirculatory model, the neurohormonal model and the biomechanical model. The hope is that this historical rendering of the evolution of modern theory and therapy for heart failure will be of some use to the growing field of pediatric heart failure.",

keywords = "Adrenergic nervous system, Edema, Heart failure, LV remodeling, Neurohormone, Renin angiotensin aldosterone system",

author = "Mann, {Douglas L.}",

note = "Funding Information: This research was supported by research funds from the N.I.H. ( RO1 HL89543 R01 HL58081 ). Publisher Copyright: {\textcopyright} 2014 Elsevier Ireland Ltd.",

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AB - Although there have been a number of attempts to develop a unifying theory that explains all aspects of the clinical syndrome of heart failure, none of these conceptual paradigms has withstood the test of time. The foregoing review will discuss four conceptual models that have informed the modern approach to treating heart failure with a reduced ejection fraction, including the cardiorenal model, the cardiocirculatory model, the neurohormonal model and the biomechanical model. The hope is that this historical rendering of the evolution of modern theory and therapy for heart failure will be of some use to the growing field of pediatric heart failure.

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The evolution of modern theory and therapy for heart failure

Abstract

Keywords

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