The evaluation of liver abnormalities in inflammatory bowel disease patients

Research output: Contribution to journalReview articlepeer-review


Purpose of reviewDevelop a clinical presentation-based approach for common liver abnormalities encountered by providers caring for patients with inflammatory bowel disease (IBD). Develop a treatment pathway for those with nonalcoholic fatty liver disease (NAFLD) arising in IBD. Discuss recent studies of prevalence, incidence, risk factors, and prognosis NAFLD in the IBD population.Recent findingsThe work-up for liver abnormalities should be approached systematically in IBD patients, similar to the general population, while still appreciating the differing prevalence of underlying liver diagnoses. Although immune mediated liver diseases occur commonly in patients with IBD, NAFLD is still the most common liver disease in patients with IBD paralleling its expanding prevalence in the general population. IBD is also an independent risk factor for NAFLD, developing in many patients with lower degrees of adiposity. Furthermore, the more severe histologic subtype, nonalcoholic steatohepatitis, is both more common and difficult to treat considering the lower effectiveness of weight loss interventions.SummaryHaving a standard approach to the most common liver disease presentations and care pathway for NAFLD will improve the quality of care provided and ease the medical decision making complexity for IBD patients. The early identification of these patients should prevent the development of irreversible complications like cirrhosis or hepatocellular carcinoma.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalCurrent opinion in gastroenterology
Issue number4
StatePublished - Jul 1 2023


  • cirrhosis
  • drug induced liver injury
  • nonalcoholic fatty liver disease
  • primary sclerosing cholangitis


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