The enigmatic parietal epithelial cell is finally getting noticed: A review

Takamoto Ohse, Jeffrey W. Pippin, Alice M. Chang, Ronald D. Krofft, Jeffrey H. Miner, Michael R. Vaughan, Stuart J. Shankland

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Although the normal glomerulus comprises four resident cell types, least is known about the parietal epithelial cells (PECs). This comprehensive review addresses the cellular origin of PECs, discusses the normal structure and protein makeup of PECs, describes PEC function, and defines the responses to injury in disease and how these events lead to clinical events. The data show that PECs have unique properties and that new functions are being recognized such as their role in differentiating into podocytes during disease.

Original languageEnglish
Pages (from-to)1225-1238
Number of pages14
JournalKidney International
Volume76
Issue number12
DOIs
StatePublished - Dec 2009

Keywords

  • Albuminuria
  • Glomerulus
  • Parietal epithelial cells
  • Podocytes

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