@article{73824c2e53574d5e99a9bd13257f66cc,
title = "The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke",
abstract = "The goal of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well-powered meta- and mega-analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large-scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided.",
keywords = "MRI, big data, lesions, neuroinformatics, stroke",
author = "Liew, {Sook Lei} and Artemis Zavaliangos-Petropulu and Neda Jahanshad and Lang, {Catherine E.} and Hayward, {Kathryn S.} and Lohse, {Keith R.} and Juliano, {Julia M.} and Francesca Assogna and Baugh, {Lee A.} and Bhattacharya, {Anup K.} and Bavrina Bigjahan and Borich, {Michael R.} and Boyd, {Lara A.} and Amy Brodtmann and Buetefisch, {Cathrin M.} and Byblow, {Winston D.} and Cassidy, {Jessica M.} and Conforto, {Adriana B.} and Craddock, {R. Cameron} and Dimyan, {Michael A.} and Dula, {Adrienne N.} and Elsa Ermer and Etherton, {Mark R.} and Fercho, {Kelene A.} and Gregory, {Chris M.} and Shahram Hadidchi and Holguin, {Jess A.} and Hwang, {Darryl H.} and Simon Jung and Kautz, {Steven A.} and Khlif, {Mohamed Salah} and Nima Khoshab and Bokkyu Kim and Hosung Kim and Amy Kuceyeski and Martin Lotze and MacIntosh, {Bradley J.} and Margetis, {John L.} and Mohamed, {Feroze B.} and Fabrizio Piras and Ander Ramos-Murguialday and Genevi{\`e}ve Richard and Pamela Roberts and Robertson, {Andrew D.} and Rondina, {Jane M.} and Rost, {Natalia S.} and Nerses Sanossian and Nicolas Schweighofer and Seo, {Na Jin} and Shiroishi, {Mark S.} and Soekadar, {Surjo R.} and Gianfranco Spalletta and Stinear, {Cathy M.} and Anisha Suri and Tang, {Wai Kwong W.} and Thielman, {Gregory T.} and Daniela Vecchio and Arno Villringer and Ward, {Nick S.} and Emilio Werden and Westlye, {Lars T.} and Carolee Winstein and Wittenberg, {George F.} and Wong, {Kristin A.} and Chunshui Yu and Cramer, {Steven C.} and Thompson, {Paul M.}",
note = "Funding Information: American Heart Association; AMORSA, Grant/Award Number: FKZ 16SV7754; Brain and Behavior Research Foundation, Grant/Award Numbers: NARSAD Young Investigator Grant, P&S Fund Investigator; BrightFocus Foundation, Grant/Award Number: A2019052S; Canadian Institutes of Health Research, Grant/Award Number: PJT‐153330; Canadian Partnership for Stroke Recovery; Center for Integrated Healthcare, U.S. Department of Veterans Affairs, Grant/Award Numbers: IO1RX001667, N‐1667; Deutsche Forschungsgemeinschaft, Grant/Award Numbers: LO795/22‐1, LO795/5‐1; Einstein Stiftung Berlin; Fort{\"u}ne‐Program of the University of T{\"u}bingen, Grant/Award Number: 2422‐0‐1; H2020 European Research Council, Grant/Award Numbers: ERC‐2017‐STG‐759370, ERC‐STG‐802998; Health Research Council of New Zealand, Grant/Award Numbers: 09/164R, 11/270, 14/136; Italian Ministry of Health, Grant/Award Number: RC 15‐16‐17‐18‐19/A; Leon Levy Foundation Fellowship; Lone Star Stroke Research Consortium; Max‐Planck‐Gesellschaft; National Health and Medical Research Council, Grant/Award Numbers: 1020526, 1088449, 1094974; National Institutes of Health, Grant/Award Numbers: 5P2CHD086851, HD065438, HD086844, K01HD091283, K23NS088107, P20 GM109040, P2CHD06570, R00HD091375, R01AG059874, R01HD065438, R01HD095137, R01MH117601, R01NR015591, R01NS076348, R01NS082285, R01NS086905, R01NS090677, R01NS115845, R21HD067906, R56‐NS100528, U19NS115388, U54EB020403; National Key Research and Development Program of China, Grant/Award Number: 2018YFC1314300; Norges Forskningsr{\aa}d, Grant/Award Number: 249795; Norwegian ExtraFoundation for Health and Rehabilitation, Grant/Award Number: 2015/FO5146; South‐Eastern Norway Regional Health Authority, Grant/Award Number: 2018076; Stroke Association, Grant/Award Number: TSA 2017/04; the Bundesministerium f{\"u}r Bildung und Forschung BMBF MOTORBIC, Grant/Award Number: FKZ 13GW0053 Funding information Publisher Copyright: {\textcopyright} 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.",
year = "2022",
month = jan,
doi = "10.1002/hbm.25015",
language = "English",
volume = "43",
pages = "129--148",
journal = "Human Brain Mapping",
issn = "1065-9471",
number = "1",
}