The Emerging Role of B Lymphocytes in Cardiovascular Disease

Luigi Adamo, Cibele Rocha-Resende, Douglas L. Mann

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


B cells are traditionally known for their ability to produce antibodies in the context of adaptive immune responses. However, over the last decade B cells have been increasingly recognized as modulators of both adaptive and innate immune responses, as well as players in an important role in the pathogenesis of a variety of human diseases. Here, after briefly summarizing our current understanding of B cell biology, we present a systematic review of the literature from both animal models and human studies that highlight the important role that B lymphocytes play in cardiac and vascular disease. While many aspects of B cell biology in the vasculature and, to an even greater extent, in the heart remain unclear, B cells are emerging as key regulators of cardiovascular adaptation to injury.

Original languageEnglish
Pages (from-to)99-121
Number of pages23
JournalAnnual Review of Immunology
StatePublished - Apr 26 2020


  • B lymphocyte
  • adaptive immunity
  • cardiac injury
  • heart failure
  • innate immunity
  • vascular disease


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