The emerging Janus face of SVEP1 in development and disease

Jared S. Elenbaas; In Hyuk Jung; Ariella Coler-Reilly; Paul C. Lee; Arturo Alisio; Nathan O. Stitziel

doi:10.1016/j.molmed.2023.08.002

The emerging Janus face of SVEP1 in development and disease

Jared S. Elenbaas, In Hyuk Jung, Ariella Coler-Reilly, Paul C. Lee, Arturo Alisio, Nathan O. Stitziel

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.

Original language	English
Pages (from-to)	939-950
Number of pages	12
Journal	Trends in Molecular Medicine
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.molmed.2023.08.002
State	Published - Nov 2023

Keywords

SVEP1
aging
chronic disease
development
extracellular matrix
vascular disease

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10.1016/j.molmed.2023.08.002

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title = "The emerging Janus face of SVEP1 in development and disease",

abstract = "Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.",

keywords = "SVEP1, aging, chronic disease, development, extracellular matrix, vascular disease",

author = "Elenbaas, {Jared S.} and Jung, {In Hyuk} and Ariella Coler-Reilly and Lee, {Paul C.} and Arturo Alisio and Stitziel, {Nathan O.}",

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T1 - The emerging Janus face of SVEP1 in development and disease

AU - Elenbaas, Jared S.

AU - Jung, In Hyuk

AU - Coler-Reilly, Ariella

AU - Lee, Paul C.

AU - Alisio, Arturo

AU - Stitziel, Nathan O.

PY - 2023/11

Y1 - 2023/11

N2 - Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.

AB - Sushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascular development and disease, but its molecular and cellular mechanisms remain poorly defined. Future studies should aim to characterize these mechanisms and determine the diagnostic, prognostic, and therapeutic value of measuring or intervening on this enigmatic protein.

KW - SVEP1

KW - aging

KW - chronic disease

KW - development

KW - extracellular matrix

KW - vascular disease

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U2 - 10.1016/j.molmed.2023.08.002

DO - 10.1016/j.molmed.2023.08.002

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The emerging Janus face of SVEP1 in development and disease

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