The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade

Lana E. Kandalaft, Nathan Singh, John B. Liao, Andrea Facciabene, Jonathan S. Berek, Daniel J. Powell, George Coukos

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

In the past decade we have witnessed important advances in the treatment of gynecological cancers and have recognized their potential immunogenicity. This has opened the door to explore immune therapy not only in HPV-induced cancers but also in ovarian and endometrial cancers. Here we will review the off-target immune effects of select chemotherapy drugs commonly used to treat gynecologic cancers and novel tools that can stimulate both the adaptive and innate immune mechanisms such as novel pleiotropic cytokines, Toll-like receptors, and powerful antibodies that can target inhibitory checkpoints, thereby activating effector cellular immune mechanisms and neutralizing suppressor cells. We will also review how existing drugs can be used for combinatorial tumor therapy.

Original languageEnglish
Pages (from-to)222-233
Number of pages12
JournalGynecologic oncology
Volume116
Issue number2
DOIs
StatePublished - Feb 2010

Keywords

  • Combinatorial
  • Immunochemotherapy
  • Ovarian cancer

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