TY - JOUR
T1 - The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function
AU - Riordan, Matt M.
AU - Weiss, Edward P.
AU - Meyer, Timothy E.
AU - Ehsani, Ali A.
AU - Racette, Susan B.
AU - Villareal, Dennis T.
AU - Fontana, Luigi
AU - Holloszy, John O.
AU - Kovács, Sándor J.
PY - 2008/3
Y1 - 2008/3
N2 - Little is known about the effects of weight loss on diastolic function. Furthermore, it is not known whether both caloric restriction (CR)- and exercise (Ex)-induced weight loss have salutary effects on diastolic function. Therefore, we assessed the effects of yearlong CR (n = 12) and Ex (n = 13) interventions, which induced ∼12% weight loss, on diastolic function in healthy, nonobese (body mass index = 23.5-29.9 kg/m2) men and women aged 50 to 60 yr. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (P < 0.05). Septal peak early mitral annular velocity (E′) increased (P < 0.01) and peak E-wave velocity/E′ decreased (P < 0.05) after weight loss in the CR group. Based on the PDF-derived indexes, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (x′o), peak force (k′x′ o), and peak stored strain energy (1/2k′x′ o2). In the Ex group, k was unchanged, although septal x′o and 1/2k′x′o 2 increased significantly and k′x′o (P = 0.13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function.
AB - Little is known about the effects of weight loss on diastolic function. Furthermore, it is not known whether both caloric restriction (CR)- and exercise (Ex)-induced weight loss have salutary effects on diastolic function. Therefore, we assessed the effects of yearlong CR (n = 12) and Ex (n = 13) interventions, which induced ∼12% weight loss, on diastolic function in healthy, nonobese (body mass index = 23.5-29.9 kg/m2) men and women aged 50 to 60 yr. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (P < 0.05). Septal peak early mitral annular velocity (E′) increased (P < 0.01) and peak E-wave velocity/E′ decreased (P < 0.05) after weight loss in the CR group. Based on the PDF-derived indexes, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (x′o), peak force (k′x′ o), and peak stored strain energy (1/2k′x′ o2). In the Ex group, k was unchanged, although septal x′o and 1/2k′x′o 2 increased significantly and k′x′o (P = 0.13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function.
KW - Diastole
KW - Diet
KW - Echocardiography
KW - Tissue Doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=41549093598&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.01236.2007
DO - 10.1152/ajpheart.01236.2007
M3 - Article
C2 - 18162561
AN - SCOPUS:41549093598
VL - 294
SP - H1174-H1182
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
SN - 0363-6135
IS - 3
ER -