The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function

Matt M. Riordan, Edward P. Weiss, Timothy E. Meyer, Ali A. Ehsani, Susan B. Racette, Dennis T. Villareal, Luigi Fontana, John O. Holloszy, Sándor J. Kovács

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Little is known about the effects of weight loss on diastolic function. Furthermore, it is not known whether both caloric restriction (CR)- and exercise (Ex)-induced weight loss have salutary effects on diastolic function. Therefore, we assessed the effects of yearlong CR (n = 12) and Ex (n = 13) interventions, which induced ∼12% weight loss, on diastolic function in healthy, nonobese (body mass index = 23.5-29.9 kg/m2) men and women aged 50 to 60 yr. Recordings of Doppler transmitral flow and Doppler tissue imaging were acquired and analyzed by conventional approaches and a validated parameterized diastolic filling (PDF) formalism. Isovolumic relaxation time decreased after weight loss in both groups (P < 0.05). Septal peak early mitral annular velocity (E′) increased (P < 0.01) and peak E-wave velocity/E′ decreased (P < 0.05) after weight loss in the CR group. Based on the PDF-derived indexes, CR resulted in a decrease in global ventricular stiffness (k) and increases in longitudinal (septal annulus motion) stored elastic strain (x′o), peak force (k′x′ o), and peak stored strain energy (1/2k′x′ o2). In the Ex group, k was unchanged, although septal x′o and 1/2k′x′o 2 increased significantly and k′x′o (P = 0.13) tended to increase. We conclude that weight loss, whether induced by CR or Ex, has salutary effects on diastolic function.

Original languageEnglish
Pages (from-to)H1174-H1182
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number3
StatePublished - Mar 2008


  • Diastole
  • Diet
  • Echocardiography
  • Tissue Doppler imaging


Dive into the research topics of 'The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function'. Together they form a unique fingerprint.

Cite this