The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

Richard A. Levy; Richard E. Ostlund; Janina Brajtburg

doi:10.1007/BF02620910

The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

Richard A. Levy
, Richard E. Ostlund
, Janina Brajtburg

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [³H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

Original language	English
Pages (from-to)	26-31
Number of pages	6
Journal	In Vitro Cellular & Developmental Biology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/BF02620910
State	Published - Jan 1 1985

Keywords

LDL receptor
amphotericin B
fibroblasts
hydroxymethylglutarylcoenzyme A
insulin
lipids

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10.1007/BF02620910

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title = "The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts",

abstract = "Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.",

keywords = "LDL receptor, amphotericin B, fibroblasts, hydroxymethylglutarylcoenzyme A, insulin, lipids",

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AU - Ostlund, Richard E.

AU - Brajtburg, Janina

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N2 - Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

AB - Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

KW - LDL receptor

KW - amphotericin B

KW - fibroblasts

KW - hydroxymethylglutarylcoenzyme A

KW - insulin

KW - lipids

UR - https://www.scopus.com/pages/publications/0021853204

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DO - 10.1007/BF02620910

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The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

Abstract

Keywords

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