The effects of amphotericin B on lipid metabolism in cultured human skin fibroblasts

Richard A. Levy, Richard E. Ostlund, Janina Brajtburg

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Amphotericin B inhibits hydroxymethylglutarylcoenzyme A (HMGCoA) reductase activity and incorporation of [3H]acetate into sterols and fatty acids of human skin fibroblasts. Delivery of cholesterol to cells via the low density lipoprotein receptor pathway is not altered. The effects of amphotericin B on cell lipid metabolism are partially reversed by both potassium and insulin.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalIn Vitro Cellular & Developmental Biology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1985

Keywords

  • LDL receptor
  • amphotericin B
  • fibroblasts
  • hydroxymethylglutarylcoenzyme A
  • insulin
  • lipids

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