The Effect on Myocardial 3H-Digoxin of Magnesium Deficiency

Robert H. Goldman; Robert E. Kleiger; Esther Schweizer; Donald C. Harrison

doi:10.3181/00379727-136-35356

The Effect on Myocardial ³H-Digoxin of Magnesium Deficiency

Robert H. Goldman
, Robert E. Kleiger
, Esther Schweizer
, Donald C. Harrison

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The hearts of magnesium-deficient mice accumulate less ³H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more ³H-digoxin than controls. The difference in the initial uptake of ³H-digoxin between control and magnesium-deficient animals is not due to different blood ³H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial ³H-digoxin metabolism is discussed.

Original language	English
Pages (from-to)	747-749
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	136
Issue number	3
DOIs	https://doi.org/10.3181/00379727-136-35356
State	Published - Mar 1971

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title = "The Effect on Myocardial 3H-Digoxin of Magnesium Deficiency",

abstract = "The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.",

author = "Goldman, \{Robert H.\} and Kleiger, \{Robert E.\} and Esther Schweizer and Harrison, \{Donald C.\}",

note = "Funding Information: These studies were supported in part by NIH Grant No. HE-09058 and a grant from the Bay Area Heart Association Research Committee.",

year = "1971",

month = mar,

doi = "10.3181/00379727-136-35356",

language = "English",

volume = "136",

pages = "747--749",

journal = "Proceedings of the Society for Experimental Biology and Medicine",

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TY - JOUR

T1 - The Effect on Myocardial 3H-Digoxin of Magnesium Deficiency

AU - Goldman, Robert H.

AU - Kleiger, Robert E.

AU - Schweizer, Esther

AU - Harrison, Donald C.

N1 - Funding Information: These studies were supported in part by NIH Grant No. HE-09058 and a grant from the Bay Area Heart Association Research Committee.

PY - 1971/3

Y1 - 1971/3

N2 - The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.

AB - The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.

UR - https://www.scopus.com/pages/publications/0015032098

U2 - 10.3181/00379727-136-35356

DO - 10.3181/00379727-136-35356

M3 - Article

C2 - 5555365

AN - SCOPUS:0015032098

SN - 0037-9727

VL - 136

SP - 747

EP - 749

JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

IS - 3

ER -

The Effect on Myocardial ³H-Digoxin of Magnesium Deficiency

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