TY - JOUR
T1 - The Effect on Myocardial 3H-Digoxin of Magnesium Deficiency
AU - Goldman, Robert H.
AU - Kleiger, Robert E.
AU - Schweizer, Esther
AU - Harrison, Donald C.
N1 - Funding Information:
These studies were supported in part by NIH Grant No. HE-09058 and a grant from the Bay Area Heart Association Research Committee.
PY - 1971/3
Y1 - 1971/3
N2 - The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.
AB - The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0015032098&partnerID=8YFLogxK
U2 - 10.3181/00379727-136-35356
DO - 10.3181/00379727-136-35356
M3 - Article
C2 - 5555365
AN - SCOPUS:0015032098
VL - 136
SP - 747
EP - 749
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
SN - 0037-9727
IS - 3
ER -