The Effect on Myocardial 3H-Digoxin of Magnesium Deficiency

Robert H. Goldman, Robert E. Kleiger, Esther Schweizer, Donald C. Harrison

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The hearts of magnesium-deficient mice accumulate less 3H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more 3H-digoxin than controls. The difference in the initial uptake of 3H-digoxin between control and magnesium-deficient animals is not due to different blood 3H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial 3H-digoxin metabolism is discussed.

Original languageEnglish
Pages (from-to)747-749
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Mar 1971


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