The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis

Bang E. Qin; Chen Cheng; Chongliang Luo; Jia Liu; Xiao Feng Xu; Jiayi Tong; Dasen Yuan; Yong Chen; Fu Hua Peng; Ying Jiang

doi:10.1093/mmy/myac068

The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis

Bang E. Qin, Chen Cheng, Chongliang Luo, Jia Liu, Xiao Feng Xu, Jiayi Tong, Dasen Yuan, Yong Chen, Fu Hua Peng, Ying Jiang

Research output: Contribution to journal › Article › peer-review

Abstract

To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy. Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy. The assessment of BV was measured by a non-commercial software, uAI Research Portal. Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV. Longitudinal study showed a decrease in total brain volume (-4.65 cm3, P =. 005), regional brain volume including white matter (-2.86 cm3, P =. 031) and basal ganglia (-0.25 cm3, P =. 007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P =. 013) in CM patients in 1 year after initial therapy. Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (-7.5 cm3, P <. 05). Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P <. 01). In addition, temporal lobe atrophy was associated with corticosteroid therapy (-6.8 cm3, P <. 01). The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.

Original language	English
Article number	myac068
Journal	Medical Mycology
Volume	60
Issue number	9
DOIs	https://doi.org/10.1093/mmy/myac068
State	Published - Sep 1 2022

Keywords

HIV-negative
brain volume
cryptococcal meningitis
non-transplant
post-infectious inflammatory response syndrome
ventriculoperitoneal shunts

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10.1093/mmy/myac068

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title = "The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis",

abstract = "To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy. Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy. The assessment of BV was measured by a non-commercial software, uAI Research Portal. Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV. Longitudinal study showed a decrease in total brain volume (-4.65 cm3, P =. 005), regional brain volume including white matter (-2.86 cm3, P =. 031) and basal ganglia (-0.25 cm3, P =. 007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P =. 013) in CM patients in 1 year after initial therapy. Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (-7.5 cm3, P <. 05). Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P <. 01). In addition, temporal lobe atrophy was associated with corticosteroid therapy (-6.8 cm3, P <. 01). The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.",

keywords = "HIV-negative, brain volume, cryptococcal meningitis, non-transplant, post-infectious inflammatory response syndrome, ventriculoperitoneal shunts",

author = "Qin, {Bang E.} and Chen Cheng and Chongliang Luo and Jia Liu and Xu, {Xiao Feng} and Jiayi Tong and Dasen Yuan and Yong Chen and Peng, {Fu Hua} and Ying Jiang",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.",

year = "2022",

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T1 - The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis

AU - Qin, Bang E.

AU - Cheng, Chen

AU - Luo, Chongliang

AU - Liu, Jia

AU - Xu, Xiao Feng

AU - Tong, Jiayi

AU - Yuan, Dasen

AU - Chen, Yong

AU - Peng, Fu Hua

AU - Jiang, Ying

PY - 2022/9/1

Y1 - 2022/9/1

N2 - To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy. Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy. The assessment of BV was measured by a non-commercial software, uAI Research Portal. Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV. Longitudinal study showed a decrease in total brain volume (-4.65 cm3, P =. 005), regional brain volume including white matter (-2.86 cm3, P =. 031) and basal ganglia (-0.25 cm3, P =. 007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P =. 013) in CM patients in 1 year after initial therapy. Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (-7.5 cm3, P <. 05). Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P <. 01). In addition, temporal lobe atrophy was associated with corticosteroid therapy (-6.8 cm3, P <. 01). The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.

AB - To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy. Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy. The assessment of BV was measured by a non-commercial software, uAI Research Portal. Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV. Longitudinal study showed a decrease in total brain volume (-4.65 cm3, P =. 005), regional brain volume including white matter (-2.86 cm3, P =. 031) and basal ganglia (-0.25 cm3, P =. 007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P =. 013) in CM patients in 1 year after initial therapy. Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (-7.5 cm3, P <. 05). Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P <. 01). In addition, temporal lobe atrophy was associated with corticosteroid therapy (-6.8 cm3, P <. 01). The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.

KW - HIV-negative

KW - brain volume

KW - cryptococcal meningitis

KW - non-transplant

KW - post-infectious inflammatory response syndrome

KW - ventriculoperitoneal shunts

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VL - 60

JO - Medical Mycology

JF - Medical Mycology

IS - 9

M1 - myac068

ER -

The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis

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Keywords

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