The Effect of Topical Clonidine on Intraocular Pressure

Elizabeth Hodapp, Allan E. Kolker, Michael A. Kass, Ivan Goldberg, Bernard Becker, Mae Gordon

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


Topical 0.125% and 0.25% clonidine hydrochloride were compared with 2% pilocarpine hydrochloride and a placebo in a double-masked crossover study. Both strengths of clonidine had an ocular hypotensive effect similar in magnitude and duration to pilocarpine. Clonidine in both concentrations also significantly lowered systemic blood pressure. Further studies will be needed to establish the value and safety of clonidine in the treatment of glaucoma.

Original languageEnglish
Pages (from-to)1208-1211
Number of pages4
JournalArchives of Ophthalmology
Issue number7
StatePublished - Jul 1981


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