The Effect of Topical Clonidine on Intraocular Pressure

Elizabeth Hodapp; Allan E. Kolker; Michael A. Kass; Ivan Goldberg; Bernard Becker; Mae Gordon

doi:10.1001/archopht.1981.03930020082006

The Effect of Topical Clonidine on Intraocular Pressure

Elizabeth Hodapp, Allan E. Kolker, Michael A. Kass, Ivan Goldberg, Bernard Becker, Mae Gordon

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Abstract

Topical 0.125% and 0.25% clonidine hydrochloride were compared with 2% pilocarpine hydrochloride and a placebo in a double-masked crossover study. Both strengths of clonidine had an ocular hypotensive effect similar in magnitude and duration to pilocarpine. Clonidine in both concentrations also significantly lowered systemic blood pressure. Further studies will be needed to establish the value and safety of clonidine in the treatment of glaucoma.

Original language	English
Pages (from-to)	1208-1211
Number of pages	4
Journal	Archives of Ophthalmology
Volume	99
Issue number	7
DOIs	https://doi.org/10.1001/archopht.1981.03930020082006
State	Published - Jul 1981

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title = "The Effect of Topical Clonidine on Intraocular Pressure",

abstract = "Topical 0.125% and 0.25% clonidine hydrochloride were compared with 2% pilocarpine hydrochloride and a placebo in a double-masked crossover study. Both strengths of clonidine had an ocular hypotensive effect similar in magnitude and duration to pilocarpine. Clonidine in both concentrations also significantly lowered systemic blood pressure. Further studies will be needed to establish the value and safety of clonidine in the treatment of glaucoma.",

author = "Elizabeth Hodapp and Kolker, {Allan E.} and Kass, {Michael A.} and Ivan Goldberg and Bernard Becker and Mae Gordon",

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AU - Goldberg, Ivan

AU - Becker, Bernard

AU - Gordon, Mae

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AB - Topical 0.125% and 0.25% clonidine hydrochloride were compared with 2% pilocarpine hydrochloride and a placebo in a double-masked crossover study. Both strengths of clonidine had an ocular hypotensive effect similar in magnitude and duration to pilocarpine. Clonidine in both concentrations also significantly lowered systemic blood pressure. Further studies will be needed to establish the value and safety of clonidine in the treatment of glaucoma.

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The Effect of Topical Clonidine on Intraocular Pressure

Abstract

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