The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography

J. C. Wu, J. C. Gillin, M. S. Buchsbaum, T. Hershey, E. Hazlett, N. Sicotte, W. E. Bunney

Research output: Contribution to journalArticlepeer-review

169 Scopus citations

Abstract

This study is the first report on the effects of total sleep deprivation (about 32 h) on regional cerebral glucose metabolism during wakefulness in man, using positron emission tomography (PET) with F-18 deoxyglucose (FDG). Sleep deprivation leads to a significant reorganization of regional cerebral metabolic activity, with relative decreases in the temporal lobes and increases in visual cortex. Absolute glucose metabolic measurements indicate a decrease in thalamus, basal ganglia, white matter, and cerebellum. No overall decrease in whole brain metabolism was noted after sleep deprivation. As expected, sleep deprivation significantly reduced visual vigilance as assessed by the continuous performance test and this decrease was correlated significantly with reduced metabolic rate in thalamic, basal ganglia, and limbic regions.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalSleep
Volume14
Issue number2
StatePublished - 1991

Keywords

  • Continuous performance test
  • Humans
  • PET
  • Regional cerebral glucose metabolism
  • Sleep
  • Sleep deprivation
  • Vigilance

Fingerprint

Dive into the research topics of 'The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography'. Together they form a unique fingerprint.

Cite this